Nuclear Hormone Receptor 4A/NR4A
Nuclear Hormone Receptor 4A; Nerve Growth Factor IB-like Receptor
Nuclear Hormone Receptor 4A (NR4A) belongs to the nuclear receptor (NR) superfamily and comprises three members: NR4A1 (Nur77), NR4A2 (Nurr1), and NR4A3 (Nor1), all of which are classified as "orphan receptors" (without a clearly defined natural ligand). NR4A plays pivotal roles in various cell types, including proliferation, apoptosis, DNA repair, cellular stress, memory, endocrinology, neuronal signaling, as well as hematopoietic, immune, and metabolic processes. Furthermore, NR4A is implicated in the pathogenesis and progression of numerous diseases, such as obesity, vascular diseases, inflammation, metabolic disorders, and neurodegenerative diseases[1][2][3][4].
References:
- [1]. Wang M, et al. Brain nuclear receptors and cardiovascular function[J]. Cell & Bioscience, 2023, 13(1): 14. [Content Brief]
- [2]. Ye F, et al. Recruitment of the CoREST transcription repressor complexes by Nerve Growth factor IB-like receptor (Nurr1/NR4A2) mediates silencing of HIV in microglial cells[J]. PLoS Pathogens, 2022, 18(7): e1010110. [Content Brief]
- [3]. Yu H, et al. Dual role of NR4A1 in porcine ovarian granulosa cell differentiation and granulosa-lutein cell regression in vitro. Theriogenology. 2023 Mar 1;198:292-304. [Content Brief]
- [4]. Yang Y, et al. The orphan nuclear receptor NR4A1 attenuates oxidative stress-induced β cells apoptosis via up-regulation of glutathione peroxidase 1. Life Sci. 2018 Jun 15;203:225-232. [Content Brief]
Nuclear Hormone Receptor 4A/NR4A Isoform Specific Products
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Nuclear Hormone Receptor 4A/NR4A Inhibitors
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Nuclear Hormone Receptor 4A/NR4A Agonists
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Nuclear Hormone Receptor 4A/NR4A Antagonists
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Nuclear Hormone Receptor 4A/NR4A Activators
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Nuclear Hormone Receptor 4A/NR4A Modulators
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Nuclear Hormone Receptor 4A/NR4A Inducer
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Nuclear Hormone Receptor 4A/NR4A Degraders
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Nuclear Hormone Receptor 4A/NR4A Control
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Nuclear Hormone Receptor 4A/NR4A Ligand
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Nuclear Hormone Receptor 4A/NR4A 관련 제품 (70)
관련 제품 (70)
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Antibodies (4)
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Nuclear Hormone Receptor 4A/NR4A Isoform Comparison
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Nurr1/RXR agonist 1
0 ImagesNurr1/RXR dual agonist 1 is a dual activator of Nurr1 (EC50 = 2.6 µM) and RXR with Ks of 0.6 and 1.1 µM, respectively. Nurr1/RXR dual agonist 1 exclusively activates the heterodimer response element DR5 by selectively destabilizing the Nurr1 homodimer and stabilizing the Nurr1:RXR heterodimer. Nurr1/RXR dual agonist 1 enhances expression of a specific subset of neuroprotective Nurr1 target genes while avoiding induction of genes associated with potential off-target effects in neuronal cells. Nurr1/RXR dual agonist 1 can be used for neurodegenerative diseases research.
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Nurr1 agonist 5
0 ImagesCat. No.: HY-149608CAS No.: 3033875-32-7Nurr1 agonist 5 (compound 5o) is a neuroprotective transcription factor Nurr1 agonist with a Kd of 0.5 μM and an EC50 of 3 μM.
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NR4A agonist-2
0 ImagesCat. No.: HY-181588NR4A agonist-2 is a selective pan-NR4A agonist designed based on Vidofludimus (HY-14908), with a Kd of 0.10 μM against NR4A1, and EC50 values of 0.098 μM, 0.092 μM and 0.09 μM against Nur77, Nurr1, NOR-1, respectively. NR4A agonist-2 exhibits 47-fold selectivity over DHODH, and shows no cytotoxic activity at concentrations up to 10 μM. By binding to a specific surface pocket in the ligand-binding domain of Nurr1, NR4A agonist-2 inhibits the formation of Nurr1 homodimers, activates response elements such as NBRE, NurRE, DR5, and then potently induces the expression of neuroprotective genes including BDNF, SOD2, thereby exerting neuroprotective activity. NR4A agonist-2 can be used in the research of neurodegenerative diseases such as Parkinson's disease, dementia and multiple sclerosis.
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IP7e (Standard)
0 ImagesCat. No.: HY-110274RCAS No.: 500164-74-9
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Cytosporone B (Standard)
0 ImagesSynonyms: Csn-B (Standard); Dothiorelone G (Standard)Cytosporone B (Standard) is the analytical standard of Cytosporone B. This product is intended for research and analytical applications. Cytosporone B (Csn-B; Dothiorelone G) is a naturally occurring nuclear orphan receptor Nur77/NR4A1 agonist with an EC50 of 0.278 nM.
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NR4A1 agonist 1
0 ImagesCat. No.: HY-175725CAS No.: 1825366-87-7NR4A1 agonist 1 is a NR4A1 agonist with a Ki value of 2.96 μM. NR4A1 agonist 1 exhibits lipid-lowering activity in 3T3-L1 adipocytes, with an EC50 of 0.13 μM, significantly decreasing triglyceride (TG) accumulation and lipid droplet accumulation. NR4A1 agonist 1 can be used for the study of obesity.
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Teduglutide-Ala(13C3,15N) sodium
0 ImagesCat. No.: HY-P1624SSynonyms: ALX-0600-Ala(13C3,15N) sodiumTeduglutide-Ala(13C3,15N) (ALX-0600-Ala(13C3,15N)) sodium is the 13C- and 15N-labeled Teduglutide (HY-P1624). Teduglutide (ALX-0600) is an analog of human glucagon like peptide-2 (GLP-2). Teduglutide can activate the expression of nuclear receptor subfamily 4 group a member 1 (NR4a1)/nur77 and intestinal FXR signaling in human hepatic stellate cells, thereby improving liver inflammation and fibrosis in mice with sclerosing cholangitis. Teduglutide can alleviate intestinal dysfunction in mice, improve lung injury, alleviate obesity related neuroinflammation and cell apoptosis.
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DIM-C-pPhOCH3 (Standard)
0 ImagesCat. No.: HY-111492RCAS No.: 33985-68-1DIM-C-pPhOCH3 (Standard) is the analytical standard of DIM-C-pPhOCH3 (HY-111492). This product is intended for research and analytical applications. DIM-C-pPhOCH3 is a Nur77 agonist. Nerve growth factor-induced Bα (NGFI-Bα, Nur77) is an orphan nuclear receptor.
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Amodiaquine dihydrochloride (Standard)
0 ImagesSynonyms: Amodiaquin dihydrochloride (Standard)Amodiaquine (dihydrochloride) (Standard) is the analytical standard of Amodiaquine (dihydrochloride). This product is intended for research and analytical applications. Amodiaquine dihydrochloride (Amodiaquin dihydrochloride), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor with a Ki of 18.6 nM. Amodiaquine dihydrochloride is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect.
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Amodiaquine (Standard)
0 ImagesSynonyms: Amodiaquin (Standard)Amodiaquine (Standard) is the analytical standard of Amodiaquine. This product is intended for research and analytical applications. Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect.
