SOS1
Ras/Rac guanine nucleotide exchange factor 1
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SOS1 Related Products (90)
Related Products (90)
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SOS1 Ligand intermediate-6
0 ImagesCat. No.: HY-163583CAS No.: 3036156-01-8SOS1 Ligand intermediate-6 is an intermediate for the synthesis of SOS1 ligand and can be used to synthesize PROTACs.
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DCAI hydrochloride
0 ImagesCat. No.: HY-118692ACAS No.: 1049742-84-8DCAI hydrochloride is a KRas inhibitor with a Kd value of 1.1 mM. DCAI hydrochloride directly binds to the Ras protein and competitively inhibits SOS-mediated nucleotide release (IC50 = 155 μM) and exchange reaction (IC50 = 342 μM). DCAI hydrochloride binds to the pocket at the Ras-SOS interface and blocks the formation of the Ras-SOS complex intermediate by impeding salt bridge formation through steric hindrance and the induction of Ras conformational changes. DCAI hydrochloride is used in the study of wild-type and mutant Ras tumors.
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2C07
0 ImagesCat. No.: HY-114894CAS No.: 2230185-95-02C07 is a mutant Ras (K-RasM72C, H-RasM72C) inhibitor. 2C07 blocks the activation of PI3K through allosteric Ras modification. 2C07 binds to the modified switch II pocket (S-IIG) of Ras in both GDP- and GTP-bound states, stabilizes the GDP-bound state, disrupts the polar interactions of the canonical GTP-bound state, and inhibits SOS binding and nucleotide exchange. 2C07 can be used in cancer-related research.
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VUBI1 (Standard)
0 ImagesCat. No.: HY-111671RCAS No.: 2245237-53-8Synonyms: SOS1 activator 1 (Standard)VUBI1 (Standard) is the analytical standard of VUBI1 (HY-111671). This product is intended for research and analytical applications. VUBI1 (SOS1 activator 1) is a benzimidazole derivative and SOS1 activator with a Kd of 44 nM. VUBI1 can significantly activate RAS-GTP and regulate the phosphorylation of ERK. VUBI1 also can serve as a target ligand for synthesizing PROTACs, such as PROTAC SOS1 degrader-1 (HY-145737), to induce SOS1 degradation. VUBI1 can be used in the study of cancer.
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NSC-70220 (Standard)
0 ImagesCat. No.: HY-101796RCAS No.: 4551-00-2NSC-70220 (Standard) is the analytical standard of NSC-70220 (HY-101796). This product is intended for research and analytical applications. NSC-70220 is a selective and allosteric SOS1 inhibitor. NSC-70220 inhibits allosteric site activation, and partially inhibited catalytic site activation. NSC-70220 has an anticancer effect.
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SOS1 Ligand intermediate-5
0 ImagesCat. No.: HY-161655CAS No.: 3043923-70-9SOS1 Ligand intermediate-5 is the ligand for son of sevenless 1 (SOS1). SOS1 Ligand intermediate-5 is utilized for synthesis of PROTAC SOS1 degrader-10 (HY-161654).
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VHL Ligand intermediate-1
0 ImagesCat. No.: HY-49514CAS No.: 2380273-21-0
