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Cat. No.: HY-49514

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VHL Ligand intermediate-1

VHL Ligand intermediate-1 (intermediate 18a) is an intermediate in the synthesis of VHL E3 ubiquitin ligase ligand and can be used to synthesize PROTACs.

For research use only. We do not sell to patients.

CAS No.: 2380273-21-0
Formula: C₂₂H₂₉N₃O₄S
Molecular Weight:431.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

VHL Ligand intermediate-1 Chemical Structure

CAS No.: 2380273-21-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

VHL Ligand intermediate-1 (intermediate 18a) is an intermediate in the synthesis of VHL E3 ubiquitin ligase ligand and can be used to synthesize PROTACs^[1].

IC₅₀ & Target

VHL

All Ligands for E3 Ligase Isoforms :

Chemical Information

CAS No. 2380273-21-0
Molecular Weight 431.55
Formula C₂₂H₂₉N₃O₄S
SMILES

C[C@@H](C1=CC=C(C2=C(N=CS2)C)C=C1)NC([C@H]3N(C[C@H](C3)O)C(OC(C)(C)C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Aurigene Discovery Technologies Limited, et al. Preparation of pyridazine derivatives as SMARCA2/4 degraders. World Intellectual Property Organization, WO2019207538 A1 2019-10-31.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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VHL Ligand intermediate-1

All Ligands for E3 Ligase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

VHL Ligand intermediate-1 Related Classifications

HY-49514 Related Classifications