1049742-84-8
Chemical Structure
DCAI hydrochloride
- CAS No.: 1049742-84-8
- Formula:C11H13Cl3N2
- Molecular Weight:279.59
IUPAC Name: 2-(4,6-dichloro-2-methyl-1H-indol-3-yl)ethan-1-amine hydrochloride
InChIKey: ZHOLRBWPQNSIHI-UHFFFAOYSA-N
SMILES: ClC1=CC(NC(C)=C2CCN)=C2C(Cl)=C1.Cl
Biological Activity: DCAI hydrochloride is a KRas inhibitor with a Kd value of 1.1 mM. DCAI hydrochloride directly binds to the Ras protein and competitively inhibits SOS-mediated nucleotide release (IC50 = 155 μM) and exchange reaction (IC50 = 342 μM). DCAI hydrochloride binds to the pocket at the Ras-SOS interface and blocks the formation of the Ras-SOS complex intermediate by impeding salt bridge formation through steric hindrance and the induction of Ras conformational changes. DCAI hydrochloride is used in the study of wild-type and mutant Ras tumors[1][2].
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DCAI hydrochloride | DCAI hydrochloride is a KRas inhibitor with a Kd value of 1.1 mM. DCAI hydrochloride directly binds to the Ras protein and competitively inhibits SOS-mediated nucleotide release (IC50 = 155 μM) and exchange reaction (IC50 = 342 μM). DCAI hydrochloride binds to the pocket at the Ras-SOS interface and blocks the formation of the Ras-SOS complex intermediate by impeding salt bridge formation through steric hindrance and the induction of Ras conformational changes. DCAI hydrochloride is used in the study of wild-type and mutant Ras tumors. | |||||||||||||||||||||
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References
- [1]. Luo H, et al. Isolation and bioactivity of an angiogenesis inhibitor extracted from the cartilage of Dasyatis akajei. Asia Pacific journal of clinical nutrition. 2007;16 Suppl 1:286-9.
- [2]. Maurer T, et al. Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proceedings of the National Academy of Sciences of the United States of America. 2012 Apr 03;109(14):5299-304. [Content Brief]
