Urotensin II (114-124), human
Urotensin II (114-124), human, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.
For research use only. We do not sell to patients.
- CAS No.: 251293-28-4
- Formula: C64H85N13O18S2
- Molecular Weight:1388.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-108446
GSK 1562590 hydrochlorideUrotensin-II Receptor Antagonist -
HY-10664
SB-611812Urotensin Receptor Antagonist -
HY-10657
SB-706375Urotensin II Receptor Antagonist -
HY-P1165
Urotensin II-related peptideUrotensin II Anague -
HY-10656
SB-657510UII Receptor Antagonist -
HY-10664R
SB-611812 (Standard)Urotensin Receptor Antagonist -
HY-10658
AC-7954Urotensin Receptor Agonist -
HY-10657R
SB-706375 (Standard)Reference Standard -
HY-10656R
SB-657510 (Standard)Reference Standard -
HY-P1166
UFP-803UT Antagonist -
![[Orn5]-URP](https://file.medchemexpress.com/product_pic/hy-p1167.gif)
HY-P1167
[Orn5]-URPUT Antagonist -
![[Orn8]-Urotensin II (human)](https://file.medchemexpress.com/product_pic/hy-p1168.gif)
HY-P1168
[Orn8]-Urotensin II (human)UT Receptor Agonist
Biological Activity
Description
IC50 & Target
GPR14[1]
In Vitro
Human Urotensin II (U-II) binds to recombinant human GPR14 with high affinity, and the binding is functionally coupled to calcium mobilization. Human Urotensin II induces concentration-dependent increases in intracellular calcium in a HEK-293 cell line expressing human GPR14 (EC50=0:62±0.17 nM, n=6)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 251293-28-4
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Molecular Weight 1388.57
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Formula C64H85N13O18S2
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Sequence
Glu-Thr-Pro-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val (Disulfide bridge: Cys5-Cys7)
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Sequence Shortening
ETPDCFWKYCV (Disulfide bridge: Cys5-Cys7)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro
H2O
Peptide Solubility and Storage Guidelines:
1. Calculate the length of the peptide.
2. Calculate the overall charge of the entire peptide according to the following table:
| Contents | Assign value | |
|---|---|---|
| Acidic amino acid | Asp (D), Glu (E), and the C-terminal -COOH. | -1 |
| Basic amino acid | Arg (R), Lys (K), His (H), and the N-terminal -NH2 | +1 |
| Neutral amino acid | Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) | 0 |
3. Recommended solution:
| Overall charge of peptide | Details |
|---|---|
| Negative (<0) |
1. Try to dissolve the peptide in water first. 2. If water fails, add NH4OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide. |
| Positive (>0) |
1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO. |
| Zero (=0) |
1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration. |
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Urotensin II (114-124), human Related Classifications
HY-P1164 Related Classifications
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