Acetobromo-α-D-glucuronic acid methyl ester, 98%
Based on 1 publication(s) in Google Scholar
Acetobromo-α-D-glucuronic acid methyl ester, 98% is a glucuronosyl donor. Acetobromo-α-D-glucuronic acid methyl ester, 98% is applicable to the synthesis of other compounds.
For research use only. We do not sell to patients.
- Purity : 99.89%
- CAS No.: 21085-72-3
- Formula: C13H17BrO9
- Molecular Weight:397.17
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Storage:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Acetobromo-α-D-glucuronic acid methyl ester, 98%
More
Biological Activity
Description
In Vitro
Acetobromo-α-D-glucuronic acid methyl ester, 98%, serves as a glucuronosyl donor in the optimized Königs-Knorr reaction to prepare milligram-scale β-configured DON glucuronide conjugates[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 21085-72-3
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Appearance Solid
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Molecular Weight 397.17
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Formula C13H17BrO9
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Color White to off-white
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SMILES
CC(O[C@H]1[C@@H]([C@H](O[C@@H]([C@@H]1OC(C)=O)Br)C(OC)=O)OC(C)=O)=O
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Synonyms
Acetobromo-alpha-D-glucuronic acid methyl ester, 98%
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Biochem Pharmacol
Chemoproteomics-based profiling reveals the targeting molecular mechanism of reversal of cisplatin resistance by baicalin in head and neck squamous cell carcinoma. [Abstract]2025 Sep 21;242(Pt 3):117360. PMID: 40987408
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (251.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (12.59 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (12.59 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (279 KB)
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SDS (395 KB)
- English - EN (395 KB)
- Français - FR (395 KB)
- Deutsch - DE (395 KB)
- Norwegian - NO (395 KB)
- Español - ES (395 KB)
- Swedish - SV (395 KB)
- Italian - IT (395 KB)
- Korean - KR (395 KB)
- Portuguese - PT (395 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5178 mL | 12.5891 mL | 25.1781 mL | 62.9453 mL |
| 5 mM | 0.5036 mL | 2.5178 mL | 5.0356 mL | 12.5891 mL | |
| 10 mM | 0.2518 mL | 1.2589 mL | 2.5178 mL | 6.2945 mL | |
| 15 mM | 0.1679 mL | 0.8393 mL | 1.6785 mL | 4.1964 mL | |
| 20 mM | 0.1259 mL | 0.6295 mL | 1.2589 mL | 3.1473 mL | |
| 25 mM | 0.1007 mL | 0.5036 mL | 1.0071 mL | 2.5178 mL | |
| 30 mM | 0.0839 mL | 0.4196 mL | 0.8393 mL | 2.0982 mL | |
| 40 mM | 0.0629 mL | 0.3147 mL | 0.6295 mL | 1.5736 mL | |
| 50 mM | 0.0504 mL | 0.2518 mL | 0.5036 mL | 1.2589 mL | |
| 60 mM | 0.0420 mL | 0.2098 mL | 0.4196 mL | 1.0491 mL | |
| 80 mM | 0.0315 mL | 0.1574 mL | 0.3147 mL | 0.7868 mL | |
| 100 mM | 0.0252 mL | 0.1259 mL | 0.2518 mL | 0.6295 mL |
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