Phenyl β-D-glucopyranoside
Based on 1 Customer Validation
Phenyl β-D-glucopyranoside is a component isolated from Phellodendron amurense, which has anti-inflammatory and anti-tumor activities. Phenyl β-D-glucopyranoside inhibits nitric oxide (NO) production, and the expression of iNOS and COX-2. Phenyl β-D-glucopyranoside also inhibits the nuclear translocation of NF-κB. Phenyl β-D-glucopyranoside inhibits the expression of pro-inflammatory cytokines and related genes.
For research use only. We do not sell to patients.
- Purity: 99.85%
- CAS No.: 1464-44-4
- Formula: C12H16O6
- Molecular Weight:256.25
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-116285
n-Octyl β-D-glucopyranoside
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HY-W011849R
Phenyl β-D-glucopyranoside (Standard)
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HY-123633
4-Methylumbelliferyl β-D-Glucopyranoside
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HY-W015993
Nonyl β-D-glucopyranoside
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HY-W061616
Tri-O-benzyl-D-glucal, 97%
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HY-116284
Methyl β-D-glucopyranoside
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HY-W274569
Hexyl-β-D-glucopyranoside, 98%
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HY-15927
4-Nitrophenyl β-D-glucopyranoside
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HY-W008125
Acetobromo-α-D-glucuronic acid methyl ester, 98%
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HY-W011411
4-Nitrophenyl a-D-glucopyranoside
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HY-W039897
Methyl α-D-mannopyranoside
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HY-W039892
4-Nitrophenyl β-D-glucuronide
Biological Activity
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COX-2 |
NF-κB |
MMP-2 |
MMP-9 |
Phenyl β-D-glucopyranoside (500 μM, 24 h) significantly inhibits the expression of inflammatory factors (IL-1β, TNF-α, IL-6, COX-2, CXCL1, MCP-1) induced by LPS (HY-D1056) in Raw 264.7 cells[1].
Phenyl β-D-glucopyranoside (200 and 500 μM, 24 h) concentration dependent inhibits MMP-2 and MMP-9 enzyme activity and Ninj1 expression in Raw 264.7 cells[1].
Phenyl β-D-glucopyranoside (200 and 500 μM) inhibits adhesion to fibronectin, type I collagen, laminin, and gelatin in Raw 264.7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1464-44-4
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Appearance Solid
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Molecular Weight 256.25
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Formula C12H16O6
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Color White to off-white
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SMILES
O[C@H]([C@H]([C@@H]([C@H](O1)CO)O)O)[C@@H]1OC2=CC=CC=C2
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (390.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.76 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.76 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.9024 mL | 19.5122 mL | 39.0244 mL | 97.5610 mL |
| 5 mM | 0.7805 mL | 3.9024 mL | 7.8049 mL | 19.5122 mL | |
| 10 mM | 0.3902 mL | 1.9512 mL | 3.9024 mL | 9.7561 mL | |
| 15 mM | 0.2602 mL | 1.3008 mL | 2.6016 mL | 6.5041 mL | |
| 20 mM | 0.1951 mL | 0.9756 mL | 1.9512 mL | 4.8780 mL | |
| 25 mM | 0.1561 mL | 0.7805 mL | 1.5610 mL | 3.9024 mL | |
| 30 mM | 0.1301 mL | 0.6504 mL | 1.3008 mL | 3.2520 mL | |
| 40 mM | 0.0976 mL | 0.4878 mL | 0.9756 mL | 2.4390 mL | |
| 50 mM | 0.0780 mL | 0.3902 mL | 0.7805 mL | 1.9512 mL | |
| 60 mM | 0.0650 mL | 0.3252 mL | 0.6504 mL | 1.6260 mL | |
| 80 mM | 0.0488 mL | 0.2439 mL | 0.4878 mL | 1.2195 mL | |
| 100 mM | 0.0390 mL | 0.1951 mL | 0.3902 mL | 0.9756 mL |
Phenyl β-D-glucopyranoside Related Classifications
HY-W011849 Related Classifications
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