Amitivir
Based on 1 Customer Validation
Amitivir (LY 217896), a thiadiazole derivative, possesses broad antiviral activity against orthomyxo- and paramyxoviruses. Amitivir is effective against influenza A and B viruses.
For research use only. We do not sell to patients.
- Purity : 95.32%
- CAS No.: 111393-84-1
- Formula: C3H2N4S
- Molecular Weight:126.14
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
-
HY-13317
OseltamivirInfluenza Virus Inhibitor -
HY-17015A
PeramivirCyclopentane neuraminidase Inhibitor -
HY-145586
OnradivirAntiviral Agent -
HY-126136
ML303 -
HY-122907
JNJ4796Influenza Virus Inhibitor -
HY-13317R
Oseltamivir (Standard)Influenza Virus Inhibitor -
HY-131179
Influenza A virus-IN-1Influenza A Virus Inhibitor -
HY-14818
Laninamivir -
HY-131059
CBS1117H1N1 Inhibitor -
HY-139663
IHVR-17028Anti-Viral Agent -
HY-135646
Eleutheroside B1Anti-human Influenza Virus Agent -
HY-156048
Trifluoromethyl-tubercidinMTr1 Inhibitor
Biological Activity
Description
In Vitro
The mean 50% inhibitory concentration of Amitivir inhibits six strains of type A influenza (A/Russia, A/Brazil/11/78, A/Ann Arbor/1/57, A/Port Chalmers/1/73, A/Hong Kong/8/68 and A/X-15) ranged from 0.37 to 1.19 μg/ml. The mean 50% inhibitory concentration of Amitivir inhibits four strains of influenza B virus (B/Maryland/11/59, B/GreatLakes/1739/54, B/Singapore/3/64, B/Lee/40) ranged from 0.75 to 1.54 μg/ml[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 111393-84-1
-
Appearance Solid
-
Molecular Weight 126.14
-
Formula C3H2N4S
-
Color Light yellow to yellow
-
SMILES
N#CNC1=NN=CS1
-
Synonyms
LY 217896
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Protocols
-
Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
-
Data Sheet (266 KB)
-
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
-
Handling Instructions (2659 KB)
References
[1]. Hayden FG, et al. Oral LY217896 for prevention of experimental influenza A virus infection and illness in humans. Antimicrob Agents Chemother. 1994;38(5):1178-1181. [Content Brief]
[2]. Colacino JM, et al. Evaluation of the anti-influenza virus activities of 1,3,4-thiadiazol-2-ylcyanamide (LY217896) and its sodium salt. Antimicrob Agents Chemother. 1990;34(11):2156-2163. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Amitivir Related Classifications
HY-106817 Related Classifications
Powered by Bioz