Amotosalen
Based on 1 publication(s) in Google Scholar
Amotosalen (S-59 (free base)) is a light-activated, DNA and RNA-crosslinking psoralen compound, which is used to neutralise pathogens. Light-activated Amotosalen binds and permanently crosslinks DNA, preventing replication and thus stopping proliferation of donor T cells. Amotosalen can be used for the study of blood system pathogen reduction technology and graft-versus-host disease (GVHD).
For research use only. We do not sell to patients.
- CAS No.: 161262-29-9
- Formula: C17H19NO4
- Molecular Weight:301.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Amotosalen
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Biological Activity
When activated by light, Amotosalen binds to the nucleic acid of the pathogen and prevents replication. Light-activated Amotosalen binds and permanently crosslinks DNA, preventing replication and thus stopping proliferation of donor T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 161262-29-9
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Molecular Weight 301.34
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Formula C17H19NO4
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SMILES
O=C1OC2=C(C)C(OC(C)=C3COCCN)=C3C=C2C(C)=C1
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Synonyms
S-59 free base
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Photochem Photobiol Sci
Spectroscopic view on the interaction between the psoralen derivative amotosalen and DNA. [Abstract]2024 Apr;23(4):693-709. PMID: 38457118
Purity & Documentation
References
[1]. Amotosalen: Allogeneic Cellular Immunotherapies system, INTERCEPT Plasma System, INTERCEPT Platelet System, S 59. BioDrugs. 2003;17(1):66-8. [Content Brief]
[2]. Lanteri MC, et al. Inactivation of a broad spectrum of viruses and parasites by photochemical treatment of plasma and platelets using amotosalen and ultraviolet A light. Transfusion. 2020 Jun;60(6):1319-1331. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Amotosalen Related Classifications
HY-107004 Related Classifications
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