Anti-Mouse CD16/CD32 Antibody (2.4G2)
Based on 1 Customer Validation
Anti-Mouse CD16/CD32 Antibody (2.4G2) is an anti-mouse CD16/CD32 IgG2b monoclonal antibody. Anti-Mouse CD16/CD32 Antibody (2.4G2) can block Fcγ receptor-mediated immune responses. Anti-Mouse CD16/CD32 Antibody (2.4G2) can block the combination of CD16 and FcγRs to reduce the production of foam cells. Anti-Mouse CD16/CD32 Antibody (2.4G2) can be used for researches on atherosclerosis and autoimmune hematological disorders.
For research use only. We do not sell to patients.
- Purity: 97.02%
- Molecular Weight:150 kDa
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Rat IgG2b kappa
Mouse
CD16/CD32
Anti-Mouse CD16/CD32 Antibody (2.4G2) significantly inhibits the binding of MDALDL to J774 cells[1].
Anti-Mouse CD16/CD32 Antibody (2.4G2) (24 h) significantly reduces the production of foam cells by blocking FcγRs in RAW264.7 cells[1].
Anti-Mouse CD16/CD32 Antibody (2.4G2) (0.01 mg/mL, 6 days) inhibits anti-body secreting cells (ASC) formation and also reduces T cell cytokine levels such as IFN-γ, IL-10 and TNF-α in T cells from the spleen of F8-/- mice[2].
Anti-Mouse CD16/CD32 Antibody (2.4G2) (0.01 mg/mL, 4 days) interferes with the uptake and presentation of FVIII immune complexes by B cells from the spleen of F8-/- mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Anti-Mouse CD16/CD32 Antibody (2.4G2) (100 μg, i.p., single dose, 24 h before injection of MWReg30) reverses the pathological effects of rat antimouse platelet MWReg30 in NMRI mice[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:γ-/- mice (2-4 months)[3]
-
Dosage:8 μg/g
-
Administration:Intravenous injection (i.v.), single dose, 1 h before injection of MAb 6A6
-
Result:Maintained a baseline platelet count of 86%, significantly higher than the control group.
-
Animal Model:NMRI mice (5-7 weeks)[4]
-
Dosage:100 μg
-
Administration:Intraperitoneal injection (i.p.), single dose, 24 h before injection of MWReg30
-
Result:Prevented MWReg30 induced hypothermia and acute lung injury.
14131 [NCBI]
P08508
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
-
Product Image
in vivo Fc receptor blocking; Fc receptor blocking, flow cytometryFc receptor blocking, immunofluor
Chemical Information
-
Appearance Liquid
-
Molecular Weight 150 kDa
-
Color Colorless to light yellow
-
SMILES
[Anti-Mouse CD16/CD32 Antibody (2.4G2)]
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
-
Data Sheet (262 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
References
[1]. Zhu X, et al. Scavenger receptor function of mouse Fcγ receptor III contributes to progression of atherosclerosis in apolipoprotein E hyperlipidemic mice. J Immunol. 2014 Sep 1;193(5):2483-95. [Content Brief]
[2]. Vollack N, et al. CD32 inhibition and high dose of rhFVIII suppress murine FVIII-specific recall response by distinct mechanisms in vitro. Thromb Haemost. 2017 Aug 30;117(9):1679-1687. [Content Brief]
[3]. Clynes R, et al. Cytotoxic antibodies trigger inflammation through Fc receptors. Immunity. 1995 Jul;3(1):21-6. [Content Brief]
[4]. Nieswandt B, et al. Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice. Blood. 1999 Jul 15;94(2):684-93. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse CD16/CD32 Antibody (2.4G2) Related Classifications
HY-P99125 Related Classifications
Powered by Bioz