Anti-Mouse IL-18 Antibody (YIGIF74-1G7)
Based on 1 publication(s) in Google Scholar
Anti-Mouse IL-18 Antibody (YIGIF74-1G7) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IL-18. Anti-Mouse IL-18 Antibody (YIGIF74-1G7) can neutralize IL-18. Anti-Mouse IL-18 Antibody (YIGIF74-1G7) can be used for the researches of cancer, infection, inflammation and immunology, such as hepatocellular carcinoma and eosinophilic esophagitis.
For research use only. We do not sell to patients.
- Purity : 97.12%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Anti-Mouse IL-18 Antibody (YIGIF74-1G7)
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Biological Activity
Description
Isotype
Rat IgG2a kappa
Recommend Isotype Controls
Species Reactivity
Mouse
IC50 & Target
IL-18
In Vitro
In Vivo
Anti-Mouse IL-18 Antibody (YIGIF74-1G7) (200 μg, 3 times before infection) strongly reduces the protective effects of the T.mu-colonization in Salmonella-infected mice[2].
Anti-Mouse IL-18 Antibody (YIGIF74-1G7) (200 μg, i.p., twice a week for 3 weeks) shows anti-inflammation effect in eosinophilic esophagitis mice models[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Hepatocellular carcinoma mice models[1]
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Dosage:200 μg for the first time and 100 μg once a week
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Administration:Intraperitoneally injection
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Result:Increased IFNγ and decreased IL-6, TNFα, IL-1β, CCL2, CXCL1.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
in vivo IL-18 neutralization; in vitro IL-18 neutralization
Verified Bioactivity
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse IL-18 Antibody (YIGIF74-1G7)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Crit Rev Eukaryot Gene Expr
Foxm1-Mediated Transcriptional Inactivation of NLRP3 Inflammasome Promotes Immunosuppression in Cervical Cancer. [Abstract]2024;34(8):35-45. PMID: 39180206
Purity & Documentation
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Data Sheet (262 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Goulet DR, Atkins WM. Considerations for the Design of Antibody-Based Therapeutics. J Pharm Sci. 2020 Jan;109(1):74-103. [Content Brief]
[2]. Molgora M, et al. IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity. Nature. 2017 Nov 2;551(7678):110-114. [Content Brief]
[3]. Chudnovskiy A, et al. Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome. Cell. 2016 Oct 6;167(2):444-456.e14. [Content Brief]
[4]. Yadavalli CS, et al. Allergen-induced NLRP3/caspase1/IL-18 signaling initiate eosinophilic esophagitis and respective inhibitors protect disease pathogenesis. Commun Biol. 2023 Jul 31;6(1):763. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse IL-18 Antibody (YIGIF74-1G7) Related Classifications
HY-P990220 Related Classifications
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