Il18 - interleukin 18 Gene

Also Known as Igif; Il-18

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16173

Summary

Enables cytokine activity. Involved in lipid homeostasis; positive regulation of cell differentiation; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including interleukin-18-mediated signaling pathway; positive regulation of NIK/NF-kappaB signaling; and positive regulation of interferon-gamma production. Located in extracellular space. Is expressed in several structures, including back skin; dorsal aorta; gut; lymphatic system; and reproductive system. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Orthologous to human IL18 (interleukin 18). [provided by Alliance of Genome Resources, Apr 2022]

Il18 Products (3)

mRNA Protein Name
NM_001357221.1 NP_001344150.1 interleukin-18 isoform a
NM_001357222.1 NP_001344151.1 interleukin-18 isoform b
NM_008360.2 NP_032386.1 interleukin-18 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytokine activity IDA
IDA: Inferred from direct assay
11894098 MGI
enables cytokine activity IMP
IMP: Inferred from mutant phenotype
12829194 MGI
enables receptor ligand activity IDA
IDA: Inferred from direct assay
10227969 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within T-helper 1 cell cytokine production IDA
IDA: Inferred from direct assay
15843532 MGI
acts upstream of or within T-helper 1 cell cytokine production IGI
IGI: Inferred from genetic interaction
15843532 MGI
acts upstream of or within cell population proliferation IDA
IDA: Inferred from direct assay
15843532 MGI
acts upstream of or within cell population proliferation IGI
IGI: Inferred from genetic interaction
15843532 MGI
involved in cholesterol homeostasis IMP
IMP: Inferred from mutant phenotype
12829194 MGI
involved in defense response to Gram-positive bacterium IDA
IDA: Inferred from direct assay
30392956 MGI
involved in establishment of skin barrier IMP
IMP: Inferred from mutant phenotype
26638073 MGI
acts upstream of or within inflammatory response IGI
IGI: Inferred from genetic interaction
23132931 MGI
acts upstream of or within interleukin-18-mediated signaling pathway IDA
IDA: Inferred from direct assay
15843532 MGI
involved in interleukin-18-mediated signaling pathway IDA
IDA: Inferred from direct assay
30392956 MGI
acts upstream of or within interleukin-6 production IDA
IDA: Inferred from direct assay
15843532 MGI
acts upstream of or within natural killer cell activation IDA
IDA: Inferred from direct assay
10227969 MGI
acts upstream of or within natural killer cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
15843532 MGI
acts upstream of or within negative regulation of myoblast differentiation IMP
IMP: Inferred from mutant phenotype
23844157 MGI
acts upstream of or within neutrophil activation IDA
IDA: Inferred from direct assay
15843532 MGI
involved in positive regulation of T-helper 2 cell differentiation IMP
IMP: Inferred from mutant phenotype
12829194 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
26656097 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
19666510 MGI
involved in positive regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
26638073 MGI
involved in positive regulation of macrophage derived foam cell differentiation IMP
IMP: Inferred from mutant phenotype
12829194 MGI
involved in positive regulation of non-canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
10227969 MGI
acts upstream of or within positive regulation of type II interferon production IDA
IDA: Inferred from direct assay
10227969 MGI
acts upstream of or within positive regulation of type II interferon production IGI
IGI: Inferred from genetic interaction
15843532 MGI
involved in positive regulation of type II interferon production IMP
IMP: Inferred from mutant phenotype
11907086 MGI
involved in triglyceride homeostasis IMP
IMP: Inferred from mutant phenotype
12829194 MGI
acts upstream of type II interferon production IDA
IDA: Inferred from direct assay
10227969 MGI
Cellular Component GO Annotation Evidence References Source
is active in extracellular space IDA
IDA: Inferred from direct assay
30392956 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
15220916 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-18

  • IFN-gamma-inducing factor

  • IL-1 gamma

  • interferon gamma-inducing factor

  • interleukin-1 gamma

Recombinant Il18 Proteins

Cat. No. Product Name Accession Purity
HY-P70642 IL-18 Protein, Mouse (His) P70380 (N36-S192) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73181 IL-18 Protein, Mouse (solution) P70380 (N36-S192) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P70642AF Animal-Free IL-18 Protein, Mouse (His) P70380 (N36-S192) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-132591A Inclisiran sodium 99.08% Unkown
HY-132591 Inclisiran 99.48% Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-13205 Belnacasan Inhibitor 99.99% Phase 2
HY-149478 JT002 Inhibitor 99.54% Phase 2
HY-19676 Pralnacasan Inhibitor 99.83% Phase 2
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Phase
HY-P991083 MAS825 Inhibitor 95.83% Phase 3
HY-P99491 Camoteskimab Inhibitor 98.56% Phase 2
HY-P990591 GSK-1070806 Inhibitor 99.84% Phase 2

Pre-clinical Phase

Bioactive Molecules (51)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16990 Ac-YVAD-cmk Inhibitor 99.63% Unkown
HY-101092 QS-21-Api Activator 99.73% Unkown
HY-113298 Citraconic acid Inhibitor 99.08% Unkown
HY-150751 ODN TTAGGG 99.87% Unkown
HY-143221 AS-Inclisiran sodium 96.58% Unkown
HY-155876 NVP-DFV890 Antagonist 99.97% Unkown
HY-172162 LC-04-045 99.56% Unkown
HY-130413 Protectin D1 99.10% Unkown
HY-169996 NP3-253 Inhibitor 99.78% Unkown
HY-164426 HEI3090 Activator 99.00% Unkown
HY-123879 BAA473 99.93% Unkown
HY-156413 NLRP3 agonist 1 99.47% Unkown
HY-P10939A Ac-DMLD-CMK TFA Inhibitor 98.44% Unkown
HY-102019 NSC61610 Inhibitor 99.89% Unkown
HY-150742A ODN 2336 sodium 97.80% Unkown
HY-NP192 Sericin 0% Unkown
HY-W176629 Hydrocotarnine Inhibitor 99.70% Unkown
HY-160793 NSC80734 Inhibitor 98.08% Unkown
HY-172941 VEN-02XX Inhibitor 99.66% Unkown
HY-158024A (S)-NDT-19795 Inhibitor / Unkown
HY-RS06709 IL18BP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-147660 IMMH001 Agonist 98.10% Unkown
HY-111662 Fc 11a-2 Inhibitor 99.75% Unkown
HY-130480 Fructose-arginine Inhibitor 98.32% Unkown
HY-150742 ODN 2336 Agonist 90.74% Unkown
HY-173234 GI-Y2 Inhibitor / Unkown
HY-P4890A Relaxin H3 (human) TFA / Unkown
HY-RS06708 IL18 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174631 Human IL18 mRNA 90.9% Unkown
HY-125577 VRT-18858 Inhibitor / Unkown
HY-171589 NLRP3-IN-77 Inhibitor / Unkown
HY-175640 Troponin-IN-1 Inhibitor / Unkown
HY-178053 AHR agonist 10 / Unkown
HY-179635 GSTO1-IN-6 Inhibitor / Unkown
HY-185311 NEK7 degrader-3 / Unkown
HY-N6189 MBL-1 Inhibitor / Unkown
HY-P10939 Ac-DMLD-CMK Inhibitor / Unkown
HY-P4890 Relaxin H3 (human) / Unkown
HY-RS06710 IL18R1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06711 IL18RAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-119337 CE-2072 Inhibitor / Unkown
HY-174630 Human IL18R1 mRNA / Unkown
HY-208735 NEK7 degrader-5 / Unkown
HY-RS16685 Il18 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18310 Il18bp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19262 Il18r1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20633 Il18rap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23120 Il18 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24788 Il18bp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25751 Il18r1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27142 Il18rap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990220 Anti-Mouse IL-18 Antibody (YIGIF74-1G7) Inhibitor 97.12% Unkown
HY-P990312 ABT-325 Inhibitor 99.75% Unkown
HY-P992046 Anti-IL-18 Antibody Inhibitor / Unkown
HY-P992238 Anti-IL-18RAP Antibody / Unkown
HY-P992239 Anti-IL-18Rα Antibody / Unkown
HY-P992335 COM503 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il18 NCBI NCBI:3606