VRT-18858
VRT-18858 (RU-36384), the active metabolite of Pralnacasan (HY-19676), is a potent interleukin-1β converting enzyme (ICE) inhibitor (Ki = 1.4 nM). VRT-18858 inhibits LPS (HY-D1056)-induced IL-1β release (IC50 = 0.42 µM) and S. aureus Cowan-induced IL-1β and IL-18 release (IC50=1.3 and 2.1 µM, respectively) in human peripheral blood mononuclear cells. VRT-18858 can be used for osteoarthritis research.
For research use only. We do not sell to patients.
- CAS No.: 192756-07-3
- Formula: C24H25N5O7
- Molecular Weight:495.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IL-1β |
IL-18 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PBMC | IC50 |
0.38 μM
Compound: 2a
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Inhibition of LPS-induced IL1-beta production in human PBMC by ELISA
Inhibition of LPS-induced IL1-beta production in human PBMC by ELISA
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[PMID: 20656488] |
| PBMC | IC50 |
0.85 μM
Compound: VRT-18858
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Inhibition of LPS-induced IL-1beta release in PBMC (unknown origin)
Inhibition of LPS-induced IL-1beta release in PBMC (unknown origin)
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[PMID: 34823899] |
Chemical Information
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CAS No. 192756-07-3
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Molecular Weight 495.48
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Formula C24H25N5O7
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SMILES
O=C([C@@H](NC(C1=NC=CC2=C1C=CC=C2)=O)CC3)N([C@H](C(N[C@H](C=O)CC(O)=O)=O)CCC4)N4C3=O
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Synonyms
RU-36384
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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