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BAA473 

Cat. No.: HY-123879
Handling Instructions

BAA473 is a bile acid analog and is a potent activator of the pyrin inflammasome that induces the secretion of interleukin 18 (IL-18) through activation of the inflammasome in both myeloid and intestinal epithelial cells.

For research use only. We do not sell to patients.

BAA473 Chemical Structure

BAA473 Chemical Structure

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Description

BAA473 is a bile acid analog and is a potent activator of the pyrin inflammasome that induces the secretion of interleukin 18 (IL-18) through activation of the inflammasome in both myeloid and intestinal epithelial cells[1].

IC50 & Target

Pyrin inflammasome[1]

In Vitro

BAA473 (0-33 µM; 24 hours; THP-1-Cas9 cells) treatment induces cell death in LPS-primed THP-1-Cas9 cells[1].

Cell Viability Assay[1]

Cell Line: THP-1-Cas9 cells
Concentration: 0 µM, 0.1 µM, 0.4 µM, 1.2 µM, 3.7 µM, 11 µM, 33 µM
Incubation Time: 24 hours
Result: Induced cell death.
Molecular Weight

574.87

Formula

C₃₆H₆₂O₅

SMILES
Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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BAA473
Cat. No.:
HY-123879
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