1. Immunology/Inflammation
  2. Interleukin Related
  3. BAA473

BAA473 is a bile acid analog and is a potent activator of the pyrin inflammasome that induces the secretion of interleukin 18 (IL-18) through activation of the inflammasome in both myeloid and intestinal epithelial cells.

For research use only. We do not sell to patients.

BAA473 Chemical Structure

BAA473 Chemical Structure

CAS No. : 27240-87-5

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Description

BAA473 is a bile acid analog and is a potent activator of the pyrin inflammasome that induces the secretion of interleukin 18 (IL-18) through activation of the inflammasome in both myeloid and intestinal epithelial cells[1].

IC50 & Target

IL-1

 

In Vitro

BAA473 (0-33 µM; 24 hours; THP-1-Cas9 cells) treatment induces cell death in LPS-primed THP-1-Cas9 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: THP-1-Cas9 cells
Concentration: 0 µM, 0.1 µM, 0.4 µM, 1.2 µM, 3.7 µM, 11 µM, 33 µM
Incubation Time: 24 hours
Result: Induced cell death.
Molecular Weight

420.58

Formula

C25H40O5

CAS No.
SMILES

C[C@@]12[C@]3([H])[C@](CC[C@]1([H])C[C@@H](CC2)O)([H])[C@@]4([H])[C@]([C@@H](C3=O)O)([C@@](CC4)([H])[C@H](C)CCC(OC)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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BAA473 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
BAA473
Cat. No.:
HY-123879
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