27240-87-5
27240-87-5
Chemical Structure
BAA473
- CAS No.: 27240-87-5
- Formula:C25H40O5
- Molecular Weight:420.58
IUPAC Name: methyl (R)-4-((3R,5R,8S,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-11-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate
InChIKey: RYGJYUKSMUSEMY-SLKGKNCKSA-N
SMILES: C[C@@]12[C@]3([H])[C@](CC[C@]1([H])C[C@@H](CC2)O)([H])[C@@]4([H])[C@]([C@@H](C3=O)O)([C@@](CC4)([H])[C@H](C)CCC(OC)=O)C
Biological Activity: BAA473 is a bile acid analog and is a potent activator of the pyrin inflammasome that induces the secretion of interleukin 18 (IL-18) through activation of the inflammasome in both myeloid and intestinal epithelial cells[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
BAA473 | 99.93% | BAA473 is a bile acid analog and is a potent activator of the pyrin inflammasome that induces the secretion of interleukin 18 (IL-18) through activation of the inflammasome in both myeloid and intestinal epithelial cells. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Methyl cholate | 99.81% | Methyl cholate is a bile acid analog and a specific inhibitor of TcdB toxin from Clostridioides difficile. Methyl cholate exerts a stronger selective inhibitory effect on TcdB than on TcdA. Methyl cholate induces conformational stabilization by binding to a unique site of TcdB, thereby blocking the binding of the toxin to host receptors and its self-processing process. Methyl cholate effectively protects human fibroblasts from TcdB-induced cytopathic effects. Methyl cholate exhibits dose-dependent anti-hepatic fibrosis activity in both cellular and zebrafish models, and significantly reduces the expression levels of α-SMA and COL-I. Methyl cholate is suitable for in-depth research in the fields of Clostridioides difficile infection and hepatic fibrosis. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
12-Ketodeoxycholic acid (Standard) | 99.91% | 12-Ketodeoxycholic acid (Standard) is the analytical standard of 12-Ketodeoxycholic acid. This product is intended for research and analytical applications. 12-Ketodeoxycholic acid (12-Ketolithocholic acid) is a bile acid, metabolite from kidney. 12-Ketodeoxycholic acid can be a detectable marker for evidence of kidney injury | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
7-keto-Deoxycholic acid (Standard) | 99.97% | 7-keto-Deoxycholic acid (Standard) is the analytical standard of 7-keto-Deoxycholic acid. This product is intended for research and analytical applications. 7-keto-Deoxycholic acid is a metabolite of bile acids in Clostridium absonum. 7-keto-Deoxycholic acid is also converted from Lactobacillus and Bifidobacterium with specific condition. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Methyl desoxycholate | 98.0% | Methyl desoxycholate is an ester product. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
3α,12β-Dihydroxycholanoic acid | 97.0% | 3α,12β-Dihydroxycholanoic acid is a dihydroxy bile acid that is detectable in healthy urine samples. 3α,12β-Dihydroxycholanoic acid carries hydroxy substituents at the 3α and 12β positions of the 5β-cholanoic acid steroid skeleton. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
(R)-Ethyl 4-((3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate (Standard) | ≥98% | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
3-Epideoxycholic acid | 99.90% | 3-Epideoxycholic acid is a secondary bile acid and a microbial metabolite of Deoxycholic acid (HY-N0593). 3-Epideoxycholic acid targets FXR in dendritic cells, reduces their immunostimulatory properties, promotes the generation of Treg cells, and exerts anti-inflammatory activity. 3-Epideoxycholic acid can promote the growth of the bacterium Bacteroides. 3-Epideoxycholic acid can be used in research related to inflammatory and immune diseases as well as bacterial infections. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Deoxycholic acid | 99.94% | Deoxycholic acid (cholanoic acid), a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Deoxycholic acid-13C | 98.0% | Deoxycholic acid-13C is the 13C-labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Allodeoxycholic acid | Allodeoxycholic acid is a nucleoside metabolite. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
