AF488-conjugated CD11b Antibody (M1/70)
(Synonyms: CD11b,CD11b-AF488,M1/70)AF488-conjugated CD11b Antibody (M1/70) is a Rat-derived and AF488 conjugated monoclonal antibody, targeting to CD11b.
-
Host:
Rat
-
Isotype:
Rat IgG2b,κ
-
Application:
FC
-
Reactivity :
Human, Mouse
-
Formulation:
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
-
Conjugation:
AF488
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
|
|---|---|
| Dilution Ratio | 5 ul per 106 cells in a 100 µl suspension |
Product Details
AF488-conjugated CD11b Antibody (M1/70) is a Rat-derived and AF488 conjugated monoclonal antibody, targeting to CD11b.
-
Host Rat
-
Clonality Monoclonal
-
Species ReactivityHuman, Mouse
AF488
Unmodified
Rat IgG2b,κ
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
-
Storage & Stability
Stored at 2-8°C for 1 year, protect from light, do not freeze.
-
Shipping
Shipping with blue ice.
Background
-
Function
CD11b: Enables complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Contributes to cargo receptor activity. Involved in several processes, including central nervous system development; endocytosis; and positive regulation of neuron death. Acts upstream of or within several processes, including activated T cell proliferation; leukocyte migration; and microglia development. Located in external side of plasma membrane and nucleus. Is integral component of membrane. Part of integrin alphaM-beta2 complex. Is expressed in several structures, including central nervous system; heart; lymphatic vessel; thymus; and yolk sac. Human ortholog (s) of this gene implicated in lupus nephritis. Orthologous to human ITGAM (integrin subunit alpha M) .
-
Subcellular Localization
Cell membrane; Single-pass type I membrane protein; Membrane raft; Single-pass type I membrane protein
-
Expression
Tissue_specificity:It is mainly expressed in monocytes and granulocytes (PubMed: 1346576) . It is also expressed in neutrophils (protein level) (PubMed: 21193407) . -
Isoforms & Post-Translational Modification
CD11b has 2 isomers: P11215-1: 127179 Da (predicted) ; P11215-2: 127307 Da (predicted) .
-
Subunit
Heterodimer of an alpha and a beta subunit. ITGAM associates with ITGB2. Found in a complex with CD177 and ITGB2/CD18. Interacts with JAM3. Interacts with THBD. Interacts with complement factor H/CFH; this interaction mediates adhesion of neutrophils to pathogens leading to pathogen clearance. Interacts with TMEM268; this interaction inhibits ITGAM degradation via the endosome-lysosome pathway.
-
Synonyms
CD11b,CD11b-AF488,M1/70
Documentation
Powered by Bioz
