AZIN1 Antibody (YA8387)
(Synonyms: AZI; AZIA1; OAZI; OAZIN; ODC1L)AZIN1 Antibody (YA8387) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to AZIN1.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:2000-2500 |
Product Details
AZIN1 Antibody (YA8387) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to AZIN1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 49.4 kDa
Human recombinant protein fragment corresponding to amino acids 260-448 of human AZIN1 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
AZIN1 is an Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production[1][2].
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Subcellular Localization
Nucleus
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Expression
Tissue_Specificity: Expressed in liver -
Isoforms & Post-Translational Modification
O14977: 448 amino acids, molecular weight 49535 Da.
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Subunit
Monomer (PubMed:26305948)
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SwissProt ID
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Synonyms
AZI; AZIA1; OAZI; OAZIN; ODC1L
Documentation
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