AZIN1 Antibody (YA8387)

Art. -Nr.: HY-P88703: Data Sheet User Guide for Antibodies
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AZIN1 Antibody (YA8387) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to AZIN1.

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Beschreibung
Verweise

Beschreibung

AZIN1 Antibody (YA8387) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to AZIN1.

Host

Mouse

Clonality

Monoclonal

Molekulargewicht

Predicted band size: 49.4 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

O14977

Immunogen

Human recombinant protein fragment corresponding to amino acids 260-448 of human AZIN1 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:2000-2500

Sensitivity	Endogenous	Reinheit	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG2b

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Versand

Shipping with blue ice.

Background

Function：Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240, PubMed:26305948). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240)

Subcellular Localization：Nucleus

Expression：
Tissue_Specificity: Expressed in liver

Isoforms & Post-Translational Modification：O14977: 448 amino acids, molecular weight 49535 Da.

Subunit：Monomer (PubMed:26305948)

Synonyms

AZI; AZIA1; OAZI; OAZIN; ODC1L

Dokumentation

User Guide for Antibodies (1077 KB)

Verweise

[1]. /biology-dictionary/a549-cell.html [Content Brief]