CNOT2 Antibody (YA8379)(PBS only)

Cat. No.: HY-P88695A: Data Sheet User Guide for Antibodies
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CNOT2 Antibody (YA8379) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CNOT2.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

CNOT2 Antibody (YA8379) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CNOT2.

Host

Mouse

Molecular Weight

Predicted band size: 59.6 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q9NZN8

Immunogen

Full length human recombinant protein of human CNOT2 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000-2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG2a

Appearance

Solution

Formulation

Supplied in PBS, pH 7.4.

Shipping

Shipping with blue ice.

Background

Function：Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity

Subcellular Localization：Cytoplasm,Nucleus

Expression：
Tissue_Specificity: Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes

Isoforms & Post-Translational Modification：Q9NZN8 has 5 isomers: Q9NZN8-1: 59738 Da (predicted); Q9NZN8-2: 40818 Da (predicted); Q9NZN8-3: 22254 Da (predicted); Q9NZN8-4: 51537 Da (predicted); Q9NZN8-5: 54306 Da (predicted).

Subunit：Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits

Synonyms

CDC36; HSPC131; NOT2; NOT2H

Documentation

User Guide for Antibodies (1077 KB)