Jagged1 Antibody (YA3091)
(Synonyms: JAG1; JAGL1; Protein jagged-1; Jagged1; hJ1; CD339)Jagged1 Antibody (YA3091) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Jagged1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human
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Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 |
Product Details
Jagged1 Antibody (YA3091) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Jagged1.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 180 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 134 kDa
A synthesized peptide derived from human JAG1 aa1170-1218 aa1170-1218/1218.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Jagged1 is a Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro)[1][2][3].
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Subcellular Localization
Membrane; Single-pass type I membrane protein; Cell membrane
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Expression
Tissue_specificity:It is widely expressed in human tissues. In cervical epithelium, it is expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Its expression is upregulated in cervical squamous cell carcinoma. It is expressed in the bone marrow cell line HS-27a, which supports the long-term maintenance of immature progenitor cells. -
Isoforms & Post-Translational Modification
P78504 has 2 isomers: P78504-1: 133799 Da (predicted); P78504-2: 116579 Da (predicted).
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Subunit
Interacts with NOTCH2 and NOTCH3 (By similarity). Interacts with NOTCH1 (in the presence of calcium ions) (PubMed:18660822)
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SwissProt ID
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Synonyms
JAG1; JAGL1; Protein jagged-1; Jagged1; hJ1; CD339
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Research Field
Epigenetics and Nuclear Signaling
Documentation
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