LRP4 Antibody (YA6641)
(Synonyms: KIAA0816 antibody; LDLR dan antibody; Low density lipoprotein receptor related protein 4 antibody; Low-density lipoprotein receptor-related protein 4 antibody; LRP-4 antibody; LRP10 antibody; Lrp4 antibody; LRP4_HUMAN antibody; MEGF7 antibody; Multiple epidermal growth factor like domains 7 antibody; KIAA0816 antibody; LDLR dan antibody; Low density lipoprotein receptor related protein 4 antibody; Low-density lipoprotein receptor-related protein 4 antibody; LRP-4 antibody; LRP10 antibody; Lrp4 antibody; LRP4_HUMAN antibody; MEGF7 antibody; Multiple epidermal growth factor like domains 7 antibody; Multiple epidermal growth factor-like domains 7 antibody; )LRP4 Antibody (YA6641) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LRP4.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB
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Reactivity :
Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
|---|---|
| Dilution Ratio | 1:2000 |
Product Details
LRP4 Antibody (YA6641) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LRP4.
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Host Mouse
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Clonality Recombinant,Monoclonal
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Species ReactivityMouse, Rat
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Observed Molecular WeightObserved band size: 250 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 212 kDa
Recombinant protein within mouse LRP4 aa 1747-1905.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
The LRP4 protein, a member of the low-density lipoprotein receptor-related protein family, plays a critical role in multiple developmental and physiological processes. It functions as a co-receptor in the Wnt signaling pathway, particularly in the canonical Wnt/β-catenin cascade, where it facilitates the interaction between Wnt ligands and Frizzled receptors, thereby modulating downstream gene expression[1]. LRP4 is essential for neuromuscular junction (NMJ) formation and maintenance, acting as a key regulator in presynaptic differentiation and postsynaptic clustering of acetylcholine receptors[2]. In addition to its role in neural development, LRP4 has been implicated in bone metabolism, where it regulates osteoblast differentiation and mineralization through interactions with sclerostin and other bone-related factors[3]. Recent studies also highlight its involvement in cardiovascular function, including endothelial cell integrity and vascular smooth muscle cell behavior. Furthermore, LRP4 has emerged as a potential therapeutic target in autoimmune diseases such as myasthenia gravis, where autoantibodies against LRP4 disrupt NMJ stability[4]. These findings underscore the multifunctional nature of LRP4 across diverse biological systems.
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Subcellular Localization
Cell membrane
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Isoforms & Post-Translational Modification
Q8VI56 has two isomers: Q8VI56-1: 211954 Da (predicted); Q8VI56-2: 205373 Da (predicted).
N-glycosylation is required for cell surface location -
Subunit
Homooligomer
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SwissProt ID
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Synonyms
KIAA0816 antibody; LDLR dan antibody; Low density lipoprotein receptor related protein 4 antibody; Low-density lipoprotein receptor-related protein 4 antibody; LRP-4 antibody; LRP10 antibody; Lrp4 antibody; LRP4_HUMAN antibody; MEGF7 antibody; Multiple epidermal growth factor like domains 7 antibody; KIAA0816 antibody; LDLR dan antibody; Low density lipoprotein receptor related protein 4 antibody; Low-density lipoprotein receptor-related protein 4 antibody; LRP-4 antibody; LRP10 antibody; Lrp4 antibody; LRP4_HUMAN antibody; MEGF7 antibody; Multiple epidermal growth factor like domains 7 antibody; Multiple epidermal growth factor-like domains 7 antibody;
Documentation
[1]. Yang LM, et al. FGF20-Expressing, Wnt-Responsive Olfactory Epithelial Progenitors Regulate Underlying Turbinate Growth to Optimize Surface Area. Dev Cell. 2018 Sep 10;46(5):564-580.e5. [Content Brief]
[2]. Cooper KM, et al. Rapid remobilization of magmatic crystals kept in cold storage. Nature. 2014 Feb 27;506(7489):480-3. [Content Brief]
[3]. Ziemlewicz TJ, et al. Opportunistic Quantitative CT Bone Mineral Density Measurement at the Proximal Femur Using Routine Contrast-Enhanced Scans: Direct Comparison With DXA in 355 Adults. J Bone Miner Res. 2016 Oct;31(10):1835-1840. [Content Brief]
[4]. Wang XW, et al. [Clinical significance of hyponatremia in hip fracture in elderly patients]. Zhonghua Yi Xue Za Zhi. 2021 Feb 23;101(7):487-491. Chinese. [Content Brief]
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