Lrp4 - low density lipoprotein receptor-related protein 4 Gene

Also Known as mdig; Megf7; D230026E03; 6430526J12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 228357

Summary

Enables protein homodimerization activity and receptor tyrosine kinase binding activity. Involved in several processes, including positive regulation of presynaptic membrane organization; positive regulation of skeletal muscle acetylcholine-gated channel clustering; and synapse organization. Acts upstream of or within several processes, including animal organ development; embryonic digit morphogenesis; and regionalization. Located in neuromuscular junction and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; eye; and genitourinary system. Used to study sclerosteosis 2. Human ortholog(s) of this gene implicated in Cenani-Lenz syndactyly syndrome; congenital myasthenic syndrome 17; and sclerosteosis 2. Orthologous to human LRP4 (LDL receptor related protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Lrp4 Products (2)

mRNA Protein Name
NM_001145857.1 NP_001139329.1 low-density lipoprotein receptor-related protein 4 isoform 2 precursor
NM_172668.3 NP_766256.3 low-density lipoprotein receptor-related protein 4 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables coreceptor activity IDA
IDA: Inferred from direct assay
18848351 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18848351 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
18848351 MGI
enables receptor tyrosine kinase binding IPI
IPI: Inferred from physical interaction
18848351 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Wnt signaling pathway IDA
IDA: Inferred from direct assay
16207730 MGI
acts upstream of or within anatomical structure development IMP
IMP: Inferred from mutant phenotype
17119023 MGI
acts upstream of or within dorsal/ventral pattern formation IMP
IMP: Inferred from mutant phenotype
16207730 MGI
acts upstream of or within embryonic digit morphogenesis IMP
IMP: Inferred from mutant phenotype
16517118 MGI
acts upstream of or within embryonic limb morphogenesis IMP
IMP: Inferred from mutant phenotype
16207730 MGI
involved in enzyme-linked receptor protein signaling pathway IDA
IDA: Inferred from direct assay
18848351 MGI
involved in enzyme-linked receptor protein signaling pathway IGI
IGI: Inferred from genetic interaction
8653787 MGI
involved in enzyme-linked receptor protein signaling pathway IMP
IMP: Inferred from mutant phenotype
14622576 MGI
acts upstream of or within hair follicle development IMP
IMP: Inferred from mutant phenotype
17119023 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
17119023 MGI
involved in negative regulation of axonogenesis IMP
IMP: Inferred from mutant phenotype
22854782 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
20383322 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
20383322 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IMP
IMP: Inferred from mutant phenotype
17119023 MGI
involved in positive regulation of Rac protein signal transduction IDA
IDA: Inferred from direct assay
18848351 MGI
involved in positive regulation of peptidyl-tyrosine phosphorylation IMP
IMP: Inferred from mutant phenotype
18957220 MGI
involved in positive regulation of presynaptic membrane organization IDA
IDA: Inferred from direct assay
22854782 MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering IDA
IDA: Inferred from direct assay
18848351 MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering IGI
IGI: Inferred from genetic interaction
8653787 MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering IMP
IMP: Inferred from mutant phenotype
14622576 MGI
involved in postsynaptic membrane assembly IMP
IMP: Inferred from mutant phenotype
22038977 MGI
involved in presynaptic membrane assembly IMP
IMP: Inferred from mutant phenotype
22038977 MGI
acts upstream of or within protein localization IMP
IMP: Inferred from mutant phenotype
17119023 MGI
acts upstream of or within proximal/distal pattern formation IMP
IMP: Inferred from mutant phenotype
17119023 MGI
acts upstream of or within receptor clustering IMP
IMP: Inferred from mutant phenotype
17119023 MGI
involved in regulation of postsynapse assembly IDA
IDA: Inferred from direct assay
25407677 MGI
involved in regulation of postsynapse assembly IMP
IMP: Inferred from mutant phenotype
25407677 MGI
involved in regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
18848351 MGI
involved in skeletal muscle acetylcholine-gated channel clustering IMP
IMP: Inferred from mutant phenotype
22038977 MGI
involved in synaptic assembly at neuromuscular junction IDA
IDA: Inferred from direct assay
18957220 MGI
acts upstream of or within synaptic assembly at neuromuscular junction IMP
IMP: Inferred from mutant phenotype
17119023 MGI
Cellular Component GO Annotation Evidence References Source
located in neuromuscular junction IDA
IDA: Inferred from direct assay
18957220 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16263759 MGI
is active in synapse IDA
IDA: Inferred from direct assay
25407677 MGI
is active in synapse IEP
IEP: Inferred from expression pattern
25407677 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

low-density lipoprotein receptor-related protein 4

  • LDLR dan

  • LRP-4

Lrp4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86948 LRP4 Antibody (YA6641) WB Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03047 CORIN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07799 LRP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17975 Corin Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19911 Lrp4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26412 Lrp4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrp4 NCBI NCBI:4038