OTULIN Antibody
(Synonyms: FAM105B, OTULIN, Ubiquitin thioesterase otulin, Deubiquitinating enzyme otulin, OTU domain-containing deubiquitinase with linear linkage specificity, Ubiquitin thioesterase Gumby)OTULIN Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to OTULIN.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclin950.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:5000-8000 |
Product Details
OTULIN Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to OTULIN.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 40 kDa
Recombinant protein of human OTULIN (aa 1-352).
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclin950.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
OTULIN is a deubiquitinase that specifically cleaves linear ('Met-1'-linked) polyubiquitin chains and plays a critical role in angiogenesis, innate immunity, and the regulation of Wnt and NF-kappa-B signaling pathways. It supports angiogenesis, craniofacial, and neuronal development by modulating canonical Wnt signaling alongside the LUBAC complex. As a negative regulator of NF-kappa-B, OTULIN controls LUBAC activity by removing its autoubiquitination, thus maintaining its function. It also acts as a key suppressor of inflammation and autoimmunity by restricting excessive cytokine secretion and linear ubiquitination. During NOD2 stimulation, OTULIN limits linear ubiquitin chain formation on LUBAC to modulate innate immune responses. by similar: OTULIN primarily functions in maintaining LUBAC complex homeostasis.
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Subcellular Localization
Cytoplasm
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Isoforms & Post-Translational Modification
OTULIN: 352 amino acids, molecular weight 40,263 Da.
Ubiquitinated. Acetylated. Phosphorylated. Phosphorylation at Tyr-56 prevents interaction with RNF31; dephosphorylation promotes interaction with RNF31 and the LUBAC complex. -
Subunit
Interacts (via the PUB domain) with RNF31 (via the PIM motif); the interaction is direct.
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SwissProt ID
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Synonyms
FAM105B, OTULIN, Ubiquitin thioesterase otulin, Deubiquitinating enzyme otulin, OTU domain-containing deubiquitinase with linear linkage specificity, Ubiquitin thioesterase Gumby
Documentation
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