PARN Antibody (YA7807)
(Synonyms: DAN)PARN Antibody (YA7807) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PARN.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:100-200 |
Product Details
PARN Antibody (YA7807) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PARN.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
Human recombinant protein fragment corresponding to amino acids 1-266 of human PARN produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PARN is a 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization. Also able to recognize and trim poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability[1][2][3][4][5][6][7].
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Subcellular Localization
Nucleus,Cytoplasm,Nucleus, nucleolus
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Expression
Tissue_Specificity: Ubiquitous -
Isoforms & Post-Translational Modification
O95453 has four isomers: O95453-1: 73451 Da (predicted); O95453-2: 66574 Da (predicted); O95453-3: 67722 Da (predicted); O95453-4: 52989 Da (predicted).
Phosphorylation by MAPKAPK2, preventing GADD45A mRNA degradation after genotoxic stress -
Subunit
Homodimer (PubMed:10801819, PubMed:16281054)
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SwissProt ID
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Synonyms
DAN
Documentation
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