PIN4 Antibody (YA1641)
(Synonyms: EPVH; PAR14; PAR17)PIN4 Antibody (YA1641) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PIN4.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IP
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Reactivity :
Human, Rat, Hamster
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IP
IP: Immunoprecipitation
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:20 |
Product Details
PIN4 Antibody (YA1641) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PIN4.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Rat, Hamster
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Observed Molecular WeightObserved band size: 14 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 14 kDa
Entrez Gene: 5303 Human ; 628161 Mouse ; 69713 Mouse ;
SwissProt: Q9Y237 Human ; Q9CWW6 Mouse ;
OMIM: 300252 Human
A synthetic peptide of human PIN4
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PIN4 is an Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA; Isoform 2 binds to double-stranded DNA
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Subcellular Localization
Nucleus, nucleolus; Cytoplasm, cytoskeleton, spindle; Cytoplasm; Mitochondrion; Mitochondrion matrix
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Expression
Tissue_specificity:Isoform 2 is much more stable than isoform 1 (at protein level) . Ubiquitous. Isoform 1 and isoform 2 are expressed in kidney, liver, blood vessel, brain, mammary gland, skeletal muscle, small intestine and submandibularis. Isoform 1 transcripts are much more abundant than isoform 2 in each tissue analyzed -
Isoforms & Post-Translational Modification
Q9Y237 has 3 isomers: Q9Y237-1: 13810 Da (predicted); Q9Y237-2: 16608 Da (predicted); Q9Y237-3: 14179 Da (predicted).
Phosphorylated. Isoform 1 phosphorylation occurs both in the nucleus and the cytoplasm. Isoform 1 phosphorylation at Ser-19 does not affect its PPIase activity but is required for nuclear localization, and the dephosphorylation is a prerequisite for the binding to DNA. The unphosphorylated isoform 1 associates with the pre-rRNP complexes in the nucleus;Isoform 2 is sumoylated with SUMO2 and SUMO3 -
Subunit
Isoform 1 is found in pre-ribosomal ribonucleoprotein (pre-rRNP) complexes
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SwissProt ID
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Synonyms
EPVH; PAR14; PAR17
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Research Field
Epigenetics and Nuclear Signaling
Documentation
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