2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. PIN4 Antibody (YA1641)

PIN4 Antibody (YA1641) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PIN4.

For research use only. We do not sell to patients.

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50 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
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250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

PIN4 Antibody (YA1641) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PIN4.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Molecular Weight
Predicted band size: 14 kDa;
Observed band size: 14 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Rat, Hamster
SwissProt ID
Gene ID
Immunogen

A synthetic peptide of human PIN4
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
IP
IP: Immunoprecipitation
1:20
Sensitivity Endogenous Purity Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA; Isoform 2 binds to double-stranded DNA
Subcellular Localization：Nucleus, nucleolus; Cytoplasm, cytoskeleton, spindle; Cytoplasm; Mitochondrion; Mitochondrion matrix
Expression：
Tissue_specificity:Isoform 2 is much more stable than isoform 1 (at protein level) . Ubiquitous. Isoform 1 and isoform 2 are expressed in kidney, liver, blood vessel, brain, mammary gland, skeletal muscle, small intestine and submandibularis. Isoform 1 transcripts are much more abundant than isoform 2 in each tissue analyzed
Isoforms & Post-Translational Modification：Q9Y237 has 3 isomers: Q9Y237-1: 13810 Da (predicted); Q9Y237-2: 16608 Da (predicted); Q9Y237-3: 14179 Da (predicted).
Phosphorylated. Isoform 1 phosphorylation occurs both in the nucleus and the cytoplasm. Isoform 1 phosphorylation at Ser-19 does not affect its PPIase activity but is required for nuclear localization, and the dephosphorylation is a prerequisite for the binding to DNA. The unphosphorylated isoform 1 associates with the pre-rRNP complexes in the nucleus;Isoform 2 is sumoylated with SUMO2 and SUMO3
Subunit：Isoform 1 is found in pre-ribosomal ribonucleoprotein (pre-rRNP) complexes
Database

Entrez Gene: 5303 Human ; 628161 Mouse ; 69713 Mouse ;

SwissProt: Q9Y237 Human ; Q9CWW6 Mouse ;

OMIM: 300252 Human

Research Field

Epigenetics and Nuclear Signaling
Synonyms
EPVH; PAR14; PAR17
Documentation
User Guide for Antibodies (1077 KB)

PIN4 Antibody (YA1641) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
PIN4 Antibody (YA1641)
Cat. No.:
HY-P81896
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