PPP1R8 Antibody (YA8283)
(Synonyms: ARD-1; ARD1; NIPP-1; NIPP1; PRO2047)PPP1R8 Antibody (YA8283) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PPP1R8.
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Host:
Mouse
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Isotype:
IgG
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Application:
IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
PPP1R8 Antibody (YA8283) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PPP1R8.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 22.5 kDa
Human recombinant protein fragment corresponding to amino acids 1-225 of human PPP1R8 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PPP1R8 is an Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation|Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing
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Subcellular Localization
Nucleus,Nucleus speckle,Cytoplasm
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Expression
Tissue_Specificity: Ubiquitously expressed, with highest levels in heart and skeletal muscle, followed by brain, placenta, lung, liver and pancreas. Less abundant in kidney. The concentration and ratio between isoforms is cell-type dependent. Isoform Alpha (>90%) and isoform Beta were found in brain, heart and kidney. Isoform Gamma is mainly found in B-cells and T-lymphocytes, and has been found in 293 embryonic kidney cells -
Isoforms & Post-Translational Modification
Q12972 has three isomers: Q12972-1: 38479 Da (predicted); Q12972-2: 22711 Da (predicted); Q12972-3: 13344 Da (predicted).
May be inactivated by phosphorylation on Ser-199 or Ser-204 (By similarity) -
Subunit
Interacts with phosphorylated CDC5L, SF3B1 and MELK
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SwissProt ID
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Synonyms
ARD-1; ARD1; NIPP-1; NIPP1; PRO2047
Documentation
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