PRELID1 Antibody (YA8075)(PBS only)
(Synonyms: CGI-106; PRELI; PX19; SBBI12)PRELID1 Antibody (YA8075) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to PRELID1.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:500-800 |
Product Details
PRELID1 Antibody (YA8075) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to PRELID1.
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Host Mouse
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 25 kDa
Human recombinant protein fragment corresponding to amino acids 36-219 of human PRELID1 produced in E.coli.
Affinity purified
Non-conjugated
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PRELID1 is involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs
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Subcellular Localization
Mitochondrion,Mitochondrion intermembrane space
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Expression
Tissue_Specificity: Highly expressed in fetal liver; less expressed in fetal brain, lung, and kidney. At the adult stage, expression is drastically reduced in the liver but highly expressed in the spleen, brain, lung, lymph nodes and peripheral blood leukocytes
Induction: Up-regulated in response to activation in primary T helper cells -
Isoforms & Post-Translational Modification
Q9Y255 has two isomers: Q9Y255-1: 25181 Da (predicted); Q9Y255-2: 24068 Da (predicted).
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Subunit
Forms a complex with TRIAP1 in the mitochondrion intermembrane space
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SwissProt ID
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Synonyms
CGI-106; PRELI; PX19; SBBI12
Documentation
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