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Rab22A Antibody (YA1791)

(Synonyms: Ras-related protein Rab-22A)
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Rab22A Antibody (YA1791) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Rab22A.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, ICC/IF, IP

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

  • Conjugation:
    Non-conjugated
  • Rab22A Antibody (YA1791) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Related Products:
Top Publications Citing

Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
IP Info
IP: Immunoprecipitation
Dilution Ratio 1:1000-1:5000 1:50-1:100 1:10-1:100

Product Details

Description

Rab22A Antibody (YA1791) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Rab22A.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 22 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 22 kDa
Species Reactivity Database
Immunogen

A synthetic peptide of human RAB22A

Sensitivity

Endogenous

Purification

Affinity Purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    Rab22A plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form[1][2].

  • Subcellular Localization

    Endosome membrane; Lipid-anchor; Cell membrane; Lipid-anchor; Early endosome; Late endosome; Cell projection, ruffle; Cytoplasmic vesicle; Cytoplasmic vesicle, phagosome; Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side

  • Subunit

    Interacts directly with ZFYVE20 (By similarity). Binds EEA1 (By similarity). Interacts (in its GTP-bound form) with RABGEF1 (PubMed:21849477). Interacts (in its GTP-bound form) with RINL (PubMed:21419809)

  • SwissProt ID

    Q9UL26

  • Gene ID
    57403 [NCBI]
  • Synonyms

    Ras-related protein Rab-22A

  • Research Field

    Signal Transduction

[1]. Magadán JG, et al. Rab22a regulates the sorting of transferrin to recycling endosomes. Mol Cell Biol. 2006 Apr;26(7):2595-614. [Content Brief]

[2]. Wang L, et al. Rab22 controls NGF signaling and neurite outgrowth in PC12 cells. Mol Biol Cell. 2011 Oct;22(20):3853-60. [Content Brief]

Rab22A Antibody (YA1791) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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