SENP2 Antibody (YA5505)
(Synonyms: Sentrin-specific protease 2; Axam2; SMT3-specific isopeptidase 2; Smt3ip2; Sentrin/SUMO-specific protease SENP2; )SENP2 Antibody (YA5505) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SENP2.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, ICC/IF, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:100-500 | 1:1000-5000 |
Product Details
SENP2 Antibody (YA5505) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SENP2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 65 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 68 kDa
Synthesized peptide derived from human SENP2 AA range: 430-526
Protein G
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Livraison
Shipping with blue ice.
Background
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Function
SENP2 is a Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB. Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection[1][2][3][4][5].
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Subcellular Localization
Nucleus, nuclear pore complex; Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side; Cytoplasm
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Isoforms & Post-Translational Modification
Q9HC62 has 2 isomers: Q9HC62-1: 67855 Da (predicted); Q9HC62-2: 66358 Da (predicted).
Polyubiquitinated; which leads to proteasomal degradation -
Subunit
Binds to SUMO2 and SUMO3 (PubMed:15296745). Interacts with the C-terminal domain of NUP153 via its N-terminus (PubMed:11896061, PubMed:12192048). Interacts with MTA1 (PubMed:21965678)
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SwissProt ID
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Synonyms
Sentrin-specific protease 2; Axam2; SMT3-specific isopeptidase 2; Smt3ip2; Sentrin/SUMO-specific protease SENP2;
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