Transmembrane Protein 85 Antibody (YA2225)
(Synonyms: PIG17; TMEM85)Transmembrane Protein 85 Antibody (YA2225) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Transmembrane Protein 85.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IP
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Reactivity :
Human, Mouse, Rat, Hamster
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IP
IP: Immunoprecipitation
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:20 |
Product Details
Transmembrane Protein 85 Antibody (YA2225) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Transmembrane Protein 85.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Mouse, Rat, Hamster
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Observed Molecular WeightObserved band size: 20 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 20 kDa
Entrez Gene: 51234 Human ; 68032 Mouse ; 296049 Rat
SwissProt: Q5J8M3 Human ; Q9CZX9 Mouse ;
OMIM: 616245 Human
A synthetic peptide of human TMEM85 aa42-55.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Transmembrane Protein 85 is a Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable)[1][2][3][4][5].
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Subcellular Localization
Endoplasmic reticulum membrane; Multi-pass membrane protein
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Expression
Tissue_specificity:Isoform 1 is expressed in brain and heart. Isoform 2 is expressed in heart -
Isoforms & Post-Translational Modification
Q5J8M3 has 3 isomers: Q5J8M3-1: 20087 Da (predicted); Q5J8M3-2: 16745 Da (predicted); Q5J8M3-3: 15088 Da (predicted).
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Subunit
Component of the ER membrane protein complex (EMC)
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SwissProt ID
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Synonyms
PIG17; TMEM85
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Research Field
Cell Biology
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