EMC4 - ER membrane protein complex subunit 4 Gene

Also Known as PIG17; TMEM85

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51234

About EMC4

Cytogenetic location: 15q14 Genomic coordinates (GRCh38): 15:34,225,016-34,230,156 (from NCBI)

This gene has 13 transcripts (splice variants) and 199 orthologues. Ubiquitous expression in fat (RPKM 45.2), brain (RPKM 40.2) and 25 other tissues.

Summary

Contributes to membrane insertase activity. Involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Is integral component of endoplasmic reticulum membrane. Part of EMC complex. [provided by Alliance of Genome Resources, Apr 2022]

EMC4 Products (3)

mRNA Protein Name
NM_001286420.2 NP_001273349.1 ER membrane protein complex subunit 4 isoform b
NM_001351373.2 NP_001338302.1 ER membrane protein complex subunit 4 isoform c
NM_016454.4 NP_057538.1 ER membrane protein complex subunit 4 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to membrane insertase activity IMP
IMP: Inferred from mutant phenotype
29809151 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
31695625 GOA
Biological Process GO Annotation Evidence References Source
involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence IDA
IDA: Inferred from direct assay
29242231 GOA
involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence IMP
IMP: Inferred from mutant phenotype
29809151 GOA
involved in tail-anchored membrane protein insertion into ER membrane IDA
IDA: Inferred from direct assay
29242231 GOA
Cellular Component GO Annotation Evidence References Source
part of EMC complex IDA
IDA: Inferred from direct assay
22119785 GOA
part of EMC complex IPI
IPI: Inferred from physical interaction
32439656 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
32439656 GOA
located in membrane IDA
IDA: Inferred from direct assay
22119785 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EMC4 Protein Structure

DUF1077

DUF1077: Protein of unknown function (DUF1077) (56 - 172)

  • 0
  • 100
  • 183 a.a.
Protein Preferred Names Protein Names

ER membrane protein complex subunit 4

  • cell proliferation-inducing gene 17 protein

EMC4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EMC4 Q5J8M3 SLC2A9 Homo sapiens Q9NRM0-1
Anti Tag CoIP
31695625
Intra
EMC4 Q5J8M3 SLC2A9 Homo sapiens Q9NRM0-1
Ub Reconstruction
31695625
Intra
EMC4 Q5J8M3 SLC2A9 Homo sapiens Q9NRM0-2
Anti Tag CoIP
31695625
Cross
EMC4 Q5J8M3 P0DTD1-PRO_0000449624 SARS-CoV-2 P0DTD1-PRO_0000449624
Y2H Array
36217030
Cross: Cross-species interaction Intra: Intraspecies interaction

EMC4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82480 Transmembrane Protein 85 Antibody (YA2225) WB, IP Human, Mouse, Rat, Hamster
HY-P82480A Transmembrane Protein 85 Antibody (YA2225)(PBS only) WB, IP Human, Mouse, Rat, Hamster

Related Diseases

Diseases Alias
Ogden Syndrome

  • OGDNS

  • N-Terminal Acetyltransferase Deficiency

  • NATD

  • N-Alpha-Acetyltransferase

  • X-Linked Malformation And Infantile Lethality Syndrome

  • Premature Aging Appearance-Developmental Delay-Cardiac Arrhythmia Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04339 EMC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22157 Emc4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28679 Emc4 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta EMC4 VGNC VGNC:72124
Felis catus EMC4 VGNC VGNC:61835
Rattus norvegicus EMC4 RGD RGD:1310905
Bos taurus EMC4 VGNC VGNC:28465
Mus musculus EMC4 MGD MGI:1915282
Canis familiaris EMC4 VGNC VGNC:40334
Others EMC4 NCBI