VPS41 Antibody (YA2409)(PBS only)
(Synonyms: HVPS41; HVSP41; hVps41p)VPS41 Antibody (YA2409) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VPS41.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
VPS41 Antibody (YA2409) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VPS41.
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Host Rabbit
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 99 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 99 kDa
A synthetic peptide of human VPS41
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
VPS41 plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Acts as a component of the HOPS endosomal tethering complex. This complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo. Required for fusion of autophagosomes with lysosomes. Links the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion. Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS. Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adapter complex. May play a role in HOPS-independent function in the regulated secretory pathway[1][2][3][4][5][6][7][8][9][10][11].
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Subcellular Localization
Endosome membrane; Peripheral membrane protein; Late endosome membrane; Peripheral membrane protein; Early endosome membrane; Peripheral membrane protein; Lysosome membrane; Peripheral membrane protein; Golgi apparatus, trans-Golgi network; Cytoplasmic vesicle, clathrin-coated vesicle; Cytoplasm, cytosol
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Expression
Tissue_specificity:Expressed in cerebral cortex and cerebellum. Highly expressed in Purkinje cells -
Isoforms & Post-Translational Modification
P49754 has 3 isomers: P49754-1: 98566 Da (predicted); P49754-2: 92846 Da (predicted); P49754-3: 95924 Da (predicted).
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Subunit
Component of the homotypic fusion and vacuole protein sorting (HOPS) complex; the core of which composed of the class C Vps proteins VPS11, VPS16, VPS18 and VPS33A, is associated with VPS39 and VPS41 (PubMed:23351085, PubMed:25445562, PubMed:25908847, PubMed:33851776). Interacts with RILP, MON1B (PubMed:20434987, PubMed:25445562). Interacts with ARL8B (GTP-bound form); involved in recruitment to lysosomes and probably hierarchial assembly of the HOPS complex at lysosomal membranes (PubMed:25908847). In vitro can self-assemble into a lattice (PubMed:24210660). Associates with adapter protein complex 3 (AP-3) and clathrin:AP-3 complexes (PubMed:21411634). Interacts with STX17; this interaction is increased in the absence of TMEM39A (PubMed:31806350, PubMed:33422265). Interacts with ARL8B and PLEKHM1; the interaction mediates the recruitment of the HOPS complex to lysosomes (PubMed:21802320, PubMed:25908847, PubMed:28325809). Interacts with RAB7, RAB2A and RAB2B (By similarity). Interacts with RAB39A (GTP-bound) and RAB39B (GTP-bound); interaction with RAB39A leads to a functional HOPS complex that mediates autophagosome-lysosome membrane tethering (PubMed:37821429)
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SwissProt ID
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Synonyms
HVPS41; HVSP41; hVps41p
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Research Field
Signal Transduction
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