1. Metabolic Enzyme/Protease
    Cell Cycle/DNA Damage
  2. Ser/Thr Protease
    DNA/RNA Synthesis
  3. Antipain dihydrochloride

Antipain dihydrochloride 

Cat. No.: HY-127034
Handling Instructions

Antipain dihydrochloride is a protease inhibitor isolated from Actinomycetes. Antipain dihydrochloride inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain dihydrochloride restricts uterine DNA synthesis and function in mice.

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Antipain dihydrochloride Chemical Structure

Antipain dihydrochloride Chemical Structure

CAS No. : 37682-72-7

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Description

Antipain dihydrochloride is a protease inhibitor isolated from Actinomycetes. Antipain dihydrochloride inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain dihydrochloride restricts uterine DNA synthesis and function in mice[1][2][3][4].

In Vivo

The intact, cycling female mice received subcutaneous injections of Antipain dihydrochloride (3 mg) for 16 days, their uteri shows significant diminution in weight and total DNA when compared to untreated controls[4].
Antipain dihydrochloride (100 μg/g body wt; i.p.; at 12h intervals from 0 to 120 h or 240 to 360 h) shows inhibitory effect on Urethane-induced lung neoplasia in mice[5].

Molecular Weight

677.62

Formula

C₂₇H₄₆Cl₂N₁₀O₆

CAS No.

37682-72-7

SMILES

OC([[email protected]@H](NC(N[[email protected]@H](CCCNC(N)=N)C(N[[email protected]@H](C(C)C)C(NC(C([H])=O)CCCNC(N)=N)=O)=O)=O)CC1=CC=CC=C1)=O.[H]Cl.[H]Cl

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AntipainSer/Thr ProteaseDNA/RNA SynthesisSerine proteasesSerine endopeptidasesThreonine proteasesthrombokinasebloodcoagulationuterineDNAsynthesislungtumorInhibitorinhibitorinhibit

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Antipain dihydrochloride
Cat. No.:
HY-127034
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