A-366

7 Cited Publications
Kundenbewertung

Based on 7 publication(s) in Google Scholar

A-366, a chemical probe, is a potent, highly selective, peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP (EHMT1), respectively. A-366 shows >1000-fold selectivity over 21 other methyltransferases. A-366 is also a potent, nanomolar inhibitor of the Spindlin1-H3K4me3-interaction (IC50=182.6 nM). A-366 displays high affinity at human histamine H3 receptor (Ki=17 nM) and shows subtype selectivity among subsets of the histaminergic and dopaminergic receptor families.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

  • Reinheit: 98.13%
  • CAS. Nr.: 1527503-11-2
  • Formel: C19H27N3O2
  • Molecular Weight:329.44
  • Speicherung:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Biologische Aktivität
  • Chemical Information
  • Lösungsmittel & Löslichkeit
  • Reinheit & Dokumentation
  • Verweise
  • Help & FAQs
100 mg

Angebot einholen Auf Lager

Please select quantity
Amount: USD 0.00