MUT056399
Based on 1 Customer Validation
MUT056399 (Fab-001) is a highly potent inhibitor of the FabI enzyme of both S. aureus and E. coli with 50% inhibitory concentration IC50s of 12 nM and 58 nM, respectively.
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- Reinheit : 99.87%
- CAS. Nr.: 1269055-85-7
- Formel: C15H13F2NO3
- Molecular Weight:293.27
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
IC50 value: 12 nM (for S. aureus), 58 nM (for E. coli)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | ED50 |
>32 μg/mL
Compound: 83
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Cytotoxicity against human HepG2 cells
Cytotoxicity against human HepG2 cells
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[PMID: 23092194] |
In Vitro
MUT056399 (Fab-001) is a highly potent new inhibitor of the FabI enzyme of both Staphylococcus aureus and Escherichia coli. MUT056399 is very active against S. aureus strains, including methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. aureus (MRSA), linezolid-resistant, and multidrug-resistant strains, with MIC90s between 0.03 and 0.12 μg/ml. MUT056399 is also active against coagulase-negative staphylococci, with MIC90s between 0.12 and 4 μg/ml. MUT056399 is very active against the 118 S. aureus strains tested, including MSSA and MRSA isolates and linezolid-resistant and multidrug-resistant strains, with MIC90s between ≤0.03 and 0.12 μg/ml.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1269055-85-7
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Appearance Solid
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Molecular Weight 293.27
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Formel C15H13F2NO3
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Color White to off-white
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SMILES
CCC1=CC(O)=C(OC2=CC=C(C(N)=O)C=C2F)C=C1F
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Synonyms
Fab-001
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : ≥ 31 mg/mL (105.70 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Escaich S, et al. The MUT056399 inhibitor of FabI is a new antistaphylococcal compound. Antimicrob Agents Chemother. 2011 Oct;55(10):4692-7. [Content Brief]
[2]. Schiebel J, et al. An ordered water channel in Staphylococcus aureus FabI: unraveling the mechanism of substrate recognitionand reduction. Biochemistry. 2015 Mar 17;54(10):1943-55. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4098 mL | 17.0491 mL | 34.0983 mL | 85.2457 mL |
| 5 mM | 0.6820 mL | 3.4098 mL | 6.8197 mL | 17.0491 mL | |
| 10 mM | 0.3410 mL | 1.7049 mL | 3.4098 mL | 8.5246 mL | |
| 15 mM | 0.2273 mL | 1.1366 mL | 2.2732 mL | 5.6830 mL | |
| 20 mM | 0.1705 mL | 0.8525 mL | 1.7049 mL | 4.2623 mL | |
| 25 mM | 0.1364 mL | 0.6820 mL | 1.3639 mL | 3.4098 mL | |
| 30 mM | 0.1137 mL | 0.5683 mL | 1.1366 mL | 2.8415 mL | |
| 40 mM | 0.0852 mL | 0.4262 mL | 0.8525 mL | 2.1311 mL | |
| 50 mM | 0.0682 mL | 0.3410 mL | 0.6820 mL | 1.7049 mL | |
| 60 mM | 0.0568 mL | 0.2842 mL | 0.5683 mL | 1.4208 mL | |
| 80 mM | 0.0426 mL | 0.2131 mL | 0.4262 mL | 1.0656 mL | |
| 100 mM | 0.0341 mL | 0.1705 mL | 0.3410 mL | 0.8525 mL |
MUT056399 Related Classifications
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