Autophagy inducer 5
Autophagy inducer 5 (compound 21o) is a potent MCF-7 inhibitor (IC50: 2 μM), and a potential breast cancer inhibitor. Autophagy inducer 5 induces cellular autophagy by activating the ROS/JNK signaling pathway, which increases ROS generation and JNK phosphorylation, exerting cytotoxic effects.
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- Formel: C41H52N4O3
- Molecular Weight:648.88
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
7 μM
Compound: 21o
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Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay
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[PMID: 39106494] |
| Bel-7402 | IC50 |
3.7 μM
Compound: 21o
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Antiproliferative activity against human Bel-7402 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human Bel-7402 cells assessed as reduction in cell viability after 24 hrs by MTT assay
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[PMID: 39106494] |
| MCF-10A | IC50 |
15.4 μM
Compound: 21o
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Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability after 24 hrs by MTT assay
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[PMID: 39106494] |
| MCF7 | IC50 |
2 μM
Compound: 21o
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay
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[PMID: 39106494] |
Chemical Information
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Molecular Weight 648.88
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Formel C41H52N4O3
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SMILES
O=C([C@]1(C)CC[C@]2(C)CC[C@]3(C)[C@]4(C)C=CC5=C(C)C6=NC7=CC=C(C(NCCN(C)C)=O)C=C7N=C6C=C5C4=CC[C@@]3(C)[C@]2([H])C1)OC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Autophagy inducer 5 Related Classifications
HY-159605 Related Classifications
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