CJ-17493
Based on 1 publication(s) in Google Scholar
CJ-17493 is a neurokinin-1 (NK1) receptor antagonist, with a Ki of 0.2 nM. CJ-17493 shows moderate affinity for the verapamil-binding site of L-type Ca2+ channels (IC50 = 164 nM) and site 2 of sodium channels (IC50 = 48 nM). CJ-17493 can be used for the study of neurological diseases.
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- CAS. Nr.: 225655-10-7
- Formel: C24H29F3N2O2
- Molecular Weight:434.49
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Publications Citing Use of MedChemExpress (MCE) CJ-17493
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| IM-9 | IC50 |
<0.1 nM
Compound: (+)-1, CJ-17493
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Displacement of [3H]spiperone from NK1 receptor in human IM9 cells
Displacement of [3H]spiperone from NK1 receptor in human IM9 cells
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[PMID: 18640044] |
Chemical Information
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CAS. Nr. 225655-10-7
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Molecular Weight 434.49
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Formel C24H29F3N2O2
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SMILES
FC(F)(F)[C@@](OCC1)(C)C(C1=C2)=CC(CN[C@@H]3[C@H](C4=CC=CC=C4)NCCC3)=C2OC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Pharmaceuticals (Basel)
YM155 Inhibition of Survivin Enhances Carboplatin Efficacy in Metastatic Castration-Resistant Prostate Cancer. [Abstract]2025 Nov 18;18(11):1752. PMID: 41304997
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