LHB - luteinizing hormone subunit beta Gene

Also Known as CGB4; HH23; LSH-B; LSH-beta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3972

About LHB

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,015,980-49,019,498 (from NCBI)

This gene has 2 transcripts (splice variants), 27 orthologues, 9 paralogues and is associated with 2 phenotypes. Biased expression in pancreas (RPKM 1.7), testis (RPKM 1.1) and 7 other tissues.

Summary

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein Hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize Steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008]

LHB Products (1)

mRNA Protein Name
NM_000894.3 NP_000885.1 lutropin subunit beta precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LHB Protein Structure

Cys_knot

Cys_knot: Cystine-knot domain (27 - 130)

  • 0
  • 100
  • 141 a.a.
Protein Preferred Names Protein Names

lutropin subunit beta

  • interstitial cell stimulating hormone, beta chain

LHB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
LHB P01229 NTM Homo sapiens Q9P121-3
Validated Y2H
32296183
Intra
LHB P01229 FHL3 Homo sapiens Q13643
Validated Y2H
32296183
Intra
LHB P01229 FHL3 Homo sapiens Q13643
Y2H Array
32296183
Intra
LHB P01229 FHL3 Homo sapiens Q13643
Y2H Prey Pooling
32296183
Intra
LHB P01229 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
Intra
LHB P01229 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Intra
LHB P01229 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

LHB Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P81350 Luteinizing Hormone beta Antibody (YA1095) IHC-P Human
HY-P81350A Luteinizing Hormone beta Antibody (YA1095)(PBS only) IHC-P Human

Related Diseases

Diseases Alias
Hypogonadotropic Hypogonadism 23 With Or Without Anosmia

  • Fertile Eunuch Syndrome

  • Pasqualini Syndrome

  • HH23

  • 46,Xy Disorder Of Sex Development Due To Lhb Deficiency

  • 46,Xy Disorder Of Sex Development Due To Luteinizing Hormone Subunit Beta Deficiency

  • 46,Xy Dsd Due To Lhb Deficiency

  • 46,Xy Dsd Due To Luteinizing Hormone Subunit Beta Deficiency

  • Leydig Cell Hypoplasia Due To Lhb Deficiency

  • Leydig Cell Hypoplasia Due To Luteinizing Hormone Subunit Beta Deficiency

  • Eunuchoidism With Spermatogenesis, Normal Fsh And Low Or Normal Interstitial Cell-Stimulating Hormone

  • Hypogonadism, Hypogonadotropic, Type 23, With/Without Anosmia
Hypogonadism
Amenorrhea

  • Absence Of Menstruation

  • Amenia
Infertility
Hypogonadism, Male

  • Male Hypogonadism

  • Hypogonadism Male

  • Testicular Hypogonadism
Hypogonadotropic Hypogonadism

  • Klinefelter Syndrome

  • Klinefelter'S Syndrome

  • Xxy Syndrome

  • Xxy Trisomy

  • Hypogonadotropism

  • 47, Xxy

  • Congenital Idiopathic Hypogonadotropic Hypogonadism

  • Isolated Congenital Gonadotropin Deficiency

  • 47,Xxy Syndrome

  • 47, Xxy Syndrome

  • Klinefelters Syndrome

  • Hypogonadism

  • Klinefelter Syndrome In Males

  • Klinefelter Syndrome, Unspecified

  • Klinefelter Syndrome Karyotype 47, Xxy
Drug Psychosis

  • Drug-Induced Psychosis

  • Drug-Induced Psychotic Disorder

  • Psychoses, Substance-Induced

  • Psychoses, Drug
Drug-Induced Mental Disorder
Substance-Induced Psychosis
Pseudohermaphroditism

  • Indeterminate Sex And Pseudohermaphroditism
Male Infertility

  • Infertility, Male

  • Infertility Male

  • Male Sterility

  • Absolute Infertility
Leydig Cell Hypoplasia Type Ii

  • 46,Xy Disorder Of Sex Developement Due To Partial Lh Receptor Inactivation

  • 46,Xy Disorder Of Sex Developement Due To Partial Lh Resistance

  • 46,Xy Disorder Of Sex Developement Due To Partial Luteinizing Hormone Resistance

  • 46,Xy Dsd Due To Partial Lh Receptor Inactivation

  • 46,Xy Dsd Due To Partial Lh Resistance

  • 46,Xy Dsd Due To Partial Luteinizing Hormone Resistance

  • Leydig Cell Hypoplasia Due To Partial Lh Receptor Inactivation

  • Leydig Cell Hypoplasia Due To Partial Lh Resistance

  • Leydig Cell Hypoplasia Due To Partial Luteinizing Hormone Receptor Inactivation

  • Leydig Cell Hypoplasia Due To Partial Luteinizing Hormone Resistance

  • Leydig Cell Hypoplasia, Type Ii
Kallmann Syndrome

  • Hypogonadism With Anosmia

  • Kallman'S Syndrome

  • Anosmic Hypogonadism

  • Anosmic Idiopathic Hypogonadotropic Hypogonadism

  • Hypogonadotropic Hypogonadism And Anosmia

  • Hypogonadotropic Hypogonadism-Anosmia Syndrome

  • Olfacto-Genital Pathological Sequence

  • Familial Hypogonadism With Anosmia

  • Kallman Syndrome

  • Dysplasia Olfactogenitalis Of De Morsier

  • Kallmann'S Syndrome

  • Congenital Hypogonadotropic Hypogonadism With Anosmia
Hemophagocytic Lymphohistiocytosis, Familial, 3

  • Familial Hemophagocytic Lymphohistiocytosis 3

  • FHL3

  • Hplh3

  • Hlh3

  • Lymphohistiocytosis, Hemophagocytic, Familial, Type 3
Major Depressive Disorder

  • Seasonal Affective Disorder

  • Unipolar Depression

  • Depression

  • MDD

  • Depressive Disorder

  • Unipolar Depression, Susceptibility To

  • Major Depressive Disorder 1

  • Major Depressive Disorder, Response To Citalopram Therapy In

  • Major Depressive Disorder 2

  • Winter Depression

  • Single Major Depressive Episode

  • Sad

  • Clinical Depression

  • Major Depression

  • Depressive Syndrome

  • Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

  • Seasonal Affective Disorder, Susceptibility To

  • Recurrent Major Depression

  • Affective Disorder, Seasonal

  • Depression In A Seasonal Pattern

  • Depression

  • Seasonal

  • Major Depressive Disorder With A Seasonal Pattern

  • Seasonal Depression

  • Seasonal Mood Disorder

  • Mental Depression

  • Recurrent Major Depressive Episodes
Mental Depression

  • Depression

  • Depressive Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS02581 CGB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183101 AMPAR modulator-12 / Unkown
HY-RS07623 LHB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LHB MGD MGI:96782
Rattus norvegicus LHB RGD RGD:3006
Others LHB NCBI