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Art. -Nr.: HY-W399025

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ID110460001

ID110460001 is a full agonist of μ-opioid receptor and an agonist of δ-opioid receptor. ID110460001 exhibits high intrinsic efficacy for G protein pathway activation of μ-opioid receptor, and this property is not affected by the reduction in receptor quantity. ID110460001 acts only as a very weak partial agonist in the β-arrestin-2 pathway of both receptors, and binds to μ-opioid receptor via a specific mode. The efficacy of ID110460001 in the G protein pathway of δ-opioid receptor is sensitive to changes in receptor quantity. ID110460001 can be used in pain-related research.

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CAS. Nr.: 1110883-26-5
Formel: C₂₀H₂₄N₂O₃
Molecular Weight:340.42

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Please store the product under the recommended conditions in the Certificate of Analysis.

ID110460001 Chemical Structure

CAS. Nr.: 1110883-26-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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IC₅₀ & Target

μ Opioid Receptor/MOR

δ Opioid Receptor/DOR

Arrestin-2/β-Arrestin 1

Alle Opioid Receptor Isoform-spezifische Produkte anzeigen :

Alle Arrestin Isoform-spezifische Produkte anzeigen :

In Vitro

ID110460001 (eight-point concentration gradients; 20 min pre-incubation with irreversible antagonists) acts as a full agonist for the G protein pathway and a very weak partial agonist for the β-arrestin-2 pathway at both OPRM-overexpressing and OPRD-overexpressing HEK-293 cells, with high intrinsic efficacy at OPRM as demonstrated by maintained Emax under reduced receptor population conditions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

CAS. Nr. 1110883-26-5
Molecular Weight 340.42
Formel C₂₀H₂₄N₂O₃
SMILES

O=C(NCC(C=1C=CC=CC1)N(C)C)CC2=CC=C3OCCOC3=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Lee JH, et al. Discovery of μ,δ-Opioid Receptor Dual-Biased Agonists That Overcome the Limitation of Prior Biased Agonists. ACS Pharmacol Transl Sci. 2021;4(3):1149-1160. Published 2021 Apr 6. [Content Brief]

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Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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ID110460001

Alle Opioid Receptor Isoform-spezifische Produkte anzeigen

Alle Arrestin Isoform-spezifische Produkte anzeigen

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