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Art. -Nr.: HY-135459

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LY-289612

LY-289612 is a HIV-1 protease inhibitor, with an IC₅₀ of 1.5 nM.

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CAS. Nr.: 148314-61-8
Formel: C₃₅H₃₉N₅O₅
Molecular Weight:609.71

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

LY-289612 Chemical Structure

CAS. Nr.: 148314-61-8

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Preis

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Menge

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

LY-289612 is a HIV-1 protease inhibitor, with an IC₅₀ of 1.5 nM^[1].

IC₅₀ & Target

IC₅₀: 1.5 nM (HIV-1 protease)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	ED₅₀	23 nM Compound: 1	Concentration required for inhibitory activity against CEM cells in a whole cell assay. Concentration required for inhibitory activity against CEM cells in a whole cell assay.	10.1016/0960-894X(95)00101-X
CCRF-CEM	IC₅₀	13.67 ng/mL Compound: LY-289612	Compound was tested for whole cell antiviral activity against CEM cell lines Compound was tested for whole cell antiviral activity against CEM cell lines	10.1016/S0960-894X(01)80186-4
CCRF-CEM	IC₅₀	23 nM Compound: LY-289612	Concentration required for antiviral activity using infected CEM cells Concentration required for antiviral activity using infected CEM cells	10.1016/S0960-894X(01)80367-X
CCRF-CEM	IC₅₀	23 nM Compound: LY-289612	Concentration required for in vitro antiviral activity against HIV-1 virus infected CEM cells Concentration required for in vitro antiviral activity against HIV-1 virus infected CEM cells	10.1016/S0960-894X(01)80368-1
CCRF-CEM	IC₅₀	27 nM Compound: 1	Antiviral activity in HIV-infected CEM cells using whole cell assay Antiviral activity in HIV-infected CEM cells using whole cell assay	10.1016/0960-894X(95)00102-Y
MT2	IC₅₀	31.7 ng/mL Compound: LY-289612	Compound was tested for whole cell antiviral activity against MT2 cell lines Compound was tested for whole cell antiviral activity against MT2 cell lines	10.1016/S0960-894X(01)80186-4
MT2	IC₅₀	52 nM Compound: LY-289612	Concentration required for in vitro antiviral activity against HIV-1 virus infected MT2 cells Concentration required for in vitro antiviral activity against HIV-1 virus infected MT2 cells	10.1016/S0960-894X(01)80368-1

Chemical Information

CAS. Nr. 148314-61-8
Molecular Weight 609.71
Formel C₃₅H₃₉N₅O₅
SMILES

O=C(N[C@@H](CC1=CC=CC=C1)[C@H](O)CC2=CC=CC=C2C(NC(C)(C)C)=O)[C@@H](NC(C3=NC4=CC=CC=C4C=C3)=O)CC(N)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Shepherd T A, et al. D-amino acids as novel P2/P3 ligands for inhibitors of HIV-1 protease[J]. Bioorganic & Medicinal Chemistry Letters, 1994, 4(11): 1391-1396.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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