Orotirelin
Orotirelin (CG 3509) is a thyrotrophin-releasing hormone (TRH) analogue. Orotirelin can be used in the study of neurological diseases.
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- CAS. Nr.: 62305-86-6
- Formel: C16H19N7O5
- Molecular Weight:389.37
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biologische Aktivität
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats (270-290 g) anaesthetized with Sodium Pentobarbitone (60mg/kg, i.p.)[1]
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Dosage:0.1-1.0 μg (0.5 μL each side)
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Administration:Intracerebral injection; once
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Result:Reversed the Pentobarbitone-induced sleeping time.
Chemical Information
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CAS. Nr. 62305-86-6
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Molecular Weight 389.37
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Formel C16H19N7O5
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SMILES
O=C([C@H]1N(CCC1)C([C@@H](NC(C(NC2=O)=CC(N2)=O)=O)CC3=CNC=N3)=O)N
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Synonyms
CG 3509
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. K C Fone, et al. Involvement of 5-HT2 receptors in the behaviours produced by intrathecal administration of selected 5-HT agonists and the TRH analogue (CG 3509) to rats. Br J Pharmacol. 1989 Mar;96(3):599-608. [Content Brief]
[2]. T Sharp, et al. Analeptic effects of centrally injected TRH and analogues of TRH in the pentobarbitone-anaesthetized rat. Neuropharmacology. 1984 Mar;23(3):339-48. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)