10 Results for "

NPFF-R2

" in MedChemExpress (MCE) Product Catalog:
Products (10)

10 Results for "NPFF-R2" in MCE Product Catalog:

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Art. -Nr.: HY-P1248
CAS. Nr.: 99566-27-5
Synonyms: NPFF
Neuropeptide FF (NPFF), an octapeptide belonging to the RF-amide family of peptides, is a NPFF1 and NPFF2 receptors agonist with Ki values of 2.82 nM and 0.21 nM, respectively. Neuropeptide FF induces abstinence syndrome, exerts antiopioid and analgesic effects, releases via calcium-dependent mechanisms from rat spinal cord, regulates memory, autonomic function, and neuroendocrine function, modulates pain and opioid antinociception, reduces food intake, stimulates water intake, alters cardiovascular parameters, and shows differential activity in hypothalamic paraventricular nucleus neurons. Neuropeptide FF is present in mammalian central nervous system and periphery, with NPFF-immunoreactivity increases in rat cerebrospinal fluid during opiate tolerance, and its NPFF gene and NPFF-R2 gene are up-regulated in rat spinal cord and dorsal root ganglia during peripheral inflammation. Neuropeptide FF can be used for the research of opioid tolerance, morphine-induced analgesia, abstinence syndrome, pain, hypertension, nociception, inflammatory pain, and neuropathic pain [2] .
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Art. -Nr.: HY-124680
CAS. Nr.: 849459-86-5
Reinheit:  99.81%
Synonyms: AC-093
Forschungsgebiete:  

Neurological Disease

AC-263093 free base (AC-093) is a NPFFR2 agonist and a NPFFR1 functional antagonist, with pKi values of 6.9 and 7.0, respectively. AC-263093 free base selectively activates NPFFR2 (and inhibits NPFFR1) coupled to Gai/o proteins, thereby inhibiting adenylyl cyclase to reduce cAMP production. AC-263093 free base can be used for research on depression and anxiety-like disorders, inflammatory and neuropathic pain, and opioid tolerance [2] .
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Art. -Nr.: HY-P10380
palm11-PrRP31 is a lipidized endogenous appetite inhibitory neuropeptide (PrRP) analogue. palm11-PrRP31 is GPR10 (EC50=39 pM) and NPFF-R2 effective dual agonists. palm11-PrRP31 is able to mimic the natural function of PrRP by binding to these receptors to reduce food intake. palm11-PrRP31 can be used as a potential anti-obesity agent and for the study of neuropeptide-receptor interaction .
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Art. -Nr.: HY-P10380A
palm11-PrRP31 TFA is a lipidized endogenous appetite inhibitory neuropeptide (PrRP) analogue. palm11-PrRP31 TFA is GPR10 (EC50=39 pM) and NPFF-R2 effective dual agonists. palm11-PrRP31 TFA is able to mimic the natural function of PrRP by binding to these receptors to reduce food intake. palm11-PrRP31 TFA can be used as a potential anti-obesity agent and for the study of neuropeptide-receptor interaction .
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Art. -Nr.: HY-RS28417
Forschungsgebiete:  

Others

Npffr2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Npffr2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Art. -Nr.: HY-P10379
Forschungsgebiete:  

Others Neurological Disease

palm-PrRP31 is a potent dual receptor agonist for both GPR10 (EC50=72 pM) and NPFF-R2. palm-PrRP31 activates downstream signaling pathways through binding to its receptors, GPR10 and NPFF-R2, which results in reduced appetite and increased energy expenditure. Utilizing palm-PrRP31 facilitates the study of the mechanism of action in the nervous system, thereby elucidating the complex biological processes that regulate appetite and energy expenditure .
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Art. -Nr.: HY-186010
CAS. Nr.: 1958076-30-6
Forschungsgebiete:  

Neurological Disease

NPFFR2 modulator-1 (compound 11) is a NPFFR2 modulator.
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Art. -Nr.: HY-RS09482
Forschungsgebiete:  

Others

NPFFR2 Human Pre-designed siRNA Set A contains three designed siRNAs for NPFFR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Art. -Nr.: HY-RS21900
Forschungsgebiete:  

Others

Npffr2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Npffr2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Art. -Nr.: HY-123893
CAS. Nr.: 849335-02-0
Synonyms: AC-093 hydrochloride
Forschungsgebiete:  

Neurological Disease

AC-263093 (AC-093 hydrochloride) is a NPFFR2 agonist and a NPFFR1 functional antagonist, with pKi values of 6.9 and 7.0, respectively. AC-263093 selectively activates NPFFR2 (and inhibits NPFFR1) coupled to Gai/o proteins, thereby inhibiting adenylyl cyclase to reduce cAMP production. AC-263093 can be used for research on depression and anxiety-like disorders, inflammatory and neuropathic pain, and opioid tolerance [2] .
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