TDI-012804
TDI-012804 is a TNKS2 inhibitor that selectively inhibits intracellular endogenous TNKS2 protein. TDI-012804 increases the expression of AXIN1 protein in cells that are heterozygous (Tnks1HET) and completely knocks out (Tnks1KO) for TNKS1. TDI-012804 inhibits the proliferation of ApcQ1405X/Tnks1KO organoids (EC50 of 59.1 nM) and is selectively toxic to Tnks1KO AKP-G12D and AKP-G13D organoids.
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- CAS. Nr.: 3120102-92-0
- Formel: C30H26N4O4
- Molecular Weight:506.55
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Chemical Information
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CAS. Nr. 3120102-92-0
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Molecular Weight 506.55
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Formel C30H26N4O4
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SMILES
COC1=C(C(NC2=CC=C(C(NC(C3=CC=C(C(O)(C)C)C=C3)=N4)=O)C4=C2)=O)C=NC(C5=CC=CC=C5)=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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