Art. -Nr.: HY-N0263

Toosendanin

6 Cited Publications

Kundenbewertung

Based on 6 publication(s) in Google Scholar

Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb. et Zucc., possesses analgesic, insecticidal and anti-inflammatory activities.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.74%
CAS. Nr.: 58812-37-6
Formel: C₃₀H₃₈O₁₁
Molecular Weight:574.62

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Toosendanin Chemical Structure

CAS. Nr.: 58812-37-6

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vivo
Chemical Information
Publications (6)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb. et Zucc., possesses analgesic, insecticidal and anti-inflammatory activities^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HCC1806	IC₅₀	0.019 μM Compound: 1; TSN	Antiproliferative activity against human HCC1806 cells assessed as inhibition of cell growth by SRB assay Antiproliferative activity against human HCC1806 cells assessed as inhibition of cell growth by SRB assay	[PMID: 36781147]
MDA-MB-231	IC₅₀	0.115 μM Compound: 1; TSN	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth by SRB assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth by SRB assay	[PMID: 36781147]

In Vivo

Toosendanin (0.5 and 1 mg/kg, Intraperitoneal injection daily for 7 days) alleviates DSS-induced experimental colitis by inhibiting M1 macrophage polarization and regulating NLRP3 inflammasome and Nrf2/HO-1 signaling, and may provide a novel Chinese patent medicine for the treatment of murine colitis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Forty-eight male C57BL/6 mice weighing 20-22 g^[1].
Dosage:

0.5 and 1 mg/kg.
Administration:

Intraperitoneal injection daily for 7 days.
Result:

Protected against DSS-induced colitis in mice.
Inhibited the expression of proinflammatory cytokines in DSS-induced UC and improved oxidative stress.

Chemical Information

CAS. Nr. 58812-37-6
Appearance Solid
Molecular Weight 574.62
Formel C₃₀H₃₈O₁₁
Color White to off-white
SMILES

C[C@@]1([C@H]2OC(C)=O)[C@@]3(O[C@@H]3C[C@H]1C4=COC=C4)[C@]5(C)[C@H](O)C[C@@]6([H])[C@]([C@@H](OC7)O)(C)[C@H](OC(C)=O)C[C@H](O)[C@]67[C@@]5([H])C2=O
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (6)

All Flow CytometryELISAWBIn Vivo Efficacy Study

Sort by:

Journal Impact Factor

Eur J Pharmacol

Toosendanin inhibits T-cell proliferation through the P38 MAPK signalling pathway. [Abstract]

2024 Jun 15:973:176562. PMID: 38588767

Toosendanin purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2024 Jun 15:973:176562. [Abstract]

Toosendanin (TSN) (2.5-20 nM; 48 h) significantly inhibited theproliferation of T-cells activated by anti-human CD3/CD28 antibodies.

Toosendanin purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2024 Jun 15:973:176562. [Abstract]

Toosendanin (TSN) (2.5-10 nM; 72 h) arrested the cell cycle of activated T-cells in the G0/G1 phase.

Toosendanin purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2024 Jun 15:973:176562. [Abstract]

Toosendanin (TSN) (2.5-10 nM; 48 h) significantly inhibited the secretion of IL-17A and IL-6 levels and promoted IL-10 production by activated T-cells.

Toosendanin purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2024 Jun 15:973:176562. [Abstract]

Toosendanin (TSN) (5-20 nM; 1 h) significantly reduced the phosphorylation of P38 MAPK in activated T-cells.

Toosendanin purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2024 Jun 15:973:176562. [Abstract]

Toosendanin (TSN) (6 mg/kg; i.p.; 24 h) caused fewer liver lesions and significantly alleviated splenomegaly in C57 mice.
Int Immunopharmacol

Toosendanin alleviates dextran sulfate sodium-induced colitis by inhibiting M1 macrophage polarization and regulating NLRP3 inflammasome and Nrf2/HO-1 signaling. [Abstract]

2019 Nov;76:105909. PMID: 31520988
BMC Complement Med Ther

PLGA-based herb Toosendanin delivery system for efficient therapy of oral squamous cell carcinoma. [Abstract]

2025 Jul 2;25(1):217. PMID: 40604940
BMC Oral Health

Antitumor effect of toosendanin on oral squamous cell carcinoma via suppression of p-STAT3. [Abstract]

2023 Nov 9;23(1):846. PMID: 37946196
SSRN

2025 Jul 26.
Research Square Print

December 1st, 2022.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (174.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.7403 mL

8.7014 mL

17.4028 mL

5 mM

0.3481 mL

1.7403 mL

3.4806 mL

10 mM

0.1740 mL

0.8701 mL

1.7403 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.17 mg/mL (3.78 mM); Clear solution

This protocol yields a clear solution of ≥ 2.17 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (21.7 mg/mL) to 900 μL Corn oil, and mix evenly.

Protocol 2

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (3.62 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 3

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (3.62 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Fan H, et al. Toosendanin alleviates dextran sulfate sodium-induced colitis by inhibiting M1 macrophage polarization and regulating NLRP3 inflammasome and Nrf2/HO-1 signaling. Int Immunopharmacol. 2019 Sep 11;76:105909. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.7403 mL	8.7014 mL	17.4028 mL	43.5070 mL
	5 mM	0.3481 mL	1.7403 mL	3.4806 mL	8.7014 mL
	10 mM	0.1740 mL	0.8701 mL	1.7403 mL	4.3507 mL
	15 mM	0.1160 mL	0.5801 mL	1.1602 mL	2.9005 mL
	20 mM	0.0870 mL	0.4351 mL	0.8701 mL	2.1754 mL
	25 mM	0.0696 mL	0.3481 mL	0.6961 mL	1.7403 mL
	30 mM	0.0580 mL	0.2900 mL	0.5801 mL	1.4502 mL
	40 mM	0.0435 mL	0.2175 mL	0.4351 mL	1.0877 mL
	50 mM	0.0348 mL	0.1740 mL	0.3481 mL	0.8701 mL
	60 mM	0.0290 mL	0.1450 mL	0.2900 mL	0.7251 mL
	80 mM	0.0218 mL	0.1088 mL	0.2175 mL	0.5438 mL
	100 mM	0.0174 mL	0.0870 mL	0.1740 mL	0.4351 mL

Keywords

Toosendanin

6 Cited Publications

100 mg Angebot einholen

Subscribe to the

MedChemExpress

Newsletter

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

Toosendanin

Immunology/Inflammation Compound Library

Natural Product Library

Covalent Screening Library

Terpenoids Library

Traditional Chinese Medicine Active Compound Library

Anti-Cancer Natural Product Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Heterocyclic Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Miao Ethnicity Medicine Compound Library

Tibetan Medicine Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Natural Product Diversity Scaffold Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Toosendanin

Biologische Aktivität

Chemical Information

Publications (6)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Toosendanin

Immunology/Inflammation Compound Library

Natural Product Library

Covalent Screening Library

Terpenoids Library

Traditional Chinese Medicine Active Compound Library

Anti-Cancer Natural Product Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Heterocyclic Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Miao Ethnicity Medicine Compound Library

Tibetan Medicine Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Natural Product Diversity Scaffold Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Toosendanin

Biologische Aktivität

Chemical Information

Publications (6)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Toosendanin Related Classifications

HY-N0263 Related Classifications