ICAM4 - intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) Gene

Also Known as LW; CD242

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3386

About ICAM4

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,286,955-10,288,520 (from NCBI)

This gene has 3 transcripts (splice variants), 85 orthologues, 4 paralogues and is associated with 1 phenotype. Biased expression in lung (RPKM 3.3), bone marrow (RPKM 3.1) and 13 other tissues.

Summary

This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

ICAM4 Products (2)

mRNA Protein Name
NM_001039132.3 NP_001034221.1 intercellular adhesion molecule 4 isoform 3 precursor
NM_001544.5 NP_001535.1 intercellular adhesion molecule 4 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ICAM4 Protein Structure

ICAM_N

ICAM_N: Intercellular adhesion molecule (ICAM), N-terminal domain (48 - 135)

  • 0
  • 100
  • 200
  • 271 a.a.
Protein Preferred Names Protein Names

intercellular adhesion molecule 4

  • CD242 antigen

Related Diseases

Diseases Alias
Blood Group System, Landsteiner-Wiener

  • LW

  • Landsteiner-Wiener Blood Group System
Anemia, Congenital Dyserythropoietic, Type Iv

  • CDAN4

  • Congenital Dyserythropoietic Anemia Type Iv

  • Congenital Dyserythropoietic Anemia Type 4

  • Cda Iv

  • Cda Due To Klf1 Mutation

  • Cda Type 4

  • Cda Type Iv

  • Congenital Dyserythropoietic Anemia Due To Klf1 Mutation

  • Cda, Type Iv

  • Dyserythropoietic Anemia, Congenital, Type Iv

  • Congenital Dyserythropoietic Anaemia Due To Klf1 Mutation

  • Congenital Dyserythropoietic Anaemia Type 4

  • Congenital Dyserythropoietic Anaemia Type Iv

  • Anemia, Congenital Dyserythropoietic, 4

  • Anemia, Dyserythropoietic Congenital, Type Iv

  • Anemia, Dyserythropoietic, Congenital, Type Iv
Cd45 Deficiency
Hereditary Spherocytosis

  • Congenital Spherocytic Hemolytic Anemia

  • Spherocytic Anemia

  • Congenital Spherocytosis

  • Spherocytosis, Type 1

  • Minkowski Chauffard Syndrome

  • Hs

  • Minkowski-Chauffard Disease

  • Minkowski-Chauffard Syndrome

  • Spherocytosis Hereditary

  • Spherocytosis, Hereditary

  • Anemia, Hereditary Spherocytic Hemolytic
Sickle Cell Anemia

  • Hemoglobin Sc Disease

  • Anemia, Sickle Cell

  • Hbsc Disease

  • Sickle Cell-Hemoglobin C Disease Syndrome

  • Hb Ss Disease

  • Sickle Cell Trait

  • Drepanocytosis

  • Haemoglobin Sc Disease

  • Hb Sc Disease

  • Hb-S/Hb-C Disease

  • Hb-Ss Disease Without Crisis

  • Hemoglobin S Disease Without Crisis

  • Sickle Cell Anaemia

  • Sickle-Cell/Hb-C Disease Without Crisis

  • Sickle Cell - Hemoglobin C Disease

  • Hbs Disease

  • Hemoglobin S Disease

  • Sickling Disorder Due To Hemoglobin S

  • SKCA

  • Sickle Cell Disease

  • Sickle Cell-Hemoglobin C Disease

  • Sickle-Cell Disease Carrier

  • Sickle-Cell Heterozygous Disorder

  • Haemoglobin A-S Genotype

  • Hb-S - [Sickle Cell Haemoglobin] Carrier

  • Sickle Cell Haemoglobin Trait

  • As - [Sickle Cell Trait]

  • Hbas - [Sickle Cell Haemoglobin Trait]

  • Sickle-Cell Trait Haemoglobin Disease

  • Haemoglobin Sickle Cell Trait Disorder

  • Heterozygous Sickle Cell Trait

  • Hbas - [Heterozygous Haemoglobin S]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06515 ICAM4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20959 Icam4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27476 Icam4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ICAM4 VGNC VGNC:80599
Rattus norvegicus ICAM4 RGD RGD:1308971
Canis familiaris ICAM4 VGNC VGNC:81271
Mus musculus ICAM4 MGD MGI:1925619
Bos taurus ICAM4 VGNC VGNC:52244
Others ICAM4 NCBI