Bemotrizinol-d3
Bemotrizinol-d3 (Tinosorb S-d3) is the deuterated-labeled Bemotrizinol (HY-W099730). Bemotrizinol (Tinosorb S), a compound that can absorb ultraviolet light, has been shown to accept atomic oxygen generated by N-oxide photodeoxygenation.
For research use only. We do not sell to patients.
- Formula: C38H46D3N3O5
- Molecular Weight:630.83
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 187393-00-6
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Molecular Weight 630.83
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Formula C38H46D3N3O5
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SMILES
CCCCC(COC1=CC(O)=C(C2=NC(C3=C(O)C=C(OCC(CCCC)CC)C=C3)=NC(C4=CC=C(OC([2H])([2H])[2H])C=C4)=N2)C=C1)CC
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Synonyms
Tinosorb S-d3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Durán-Giner N, et al. Solar filters as feasible acceptors of atomic oxygen. Photochem Photobiol Sci. 2013;12(5):725-728. [Content Brief]
[2]. D'Ruiz CD, et al. Preliminary clinical pharmacokinetic evaluation of bemotrizinol - A new sunscreen active ingredient being considered for inclusion under FDA's over-the-counter (OTC) sunscreen monograph. Regul Toxicol Pharmacol. 2023 Mar;139:105344. [Content Brief]
[4]. Yap FH, et al. Active sunscreen ingredients in Australia. Australas J Dermatol. 2017 Nov;58(4):e160-e170. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)