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Activating signal cointegrator 1 complex subunit 3

Definition:

3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. Drives the splitting of stalled ribosomes, as part of the ribosome quality control trigger (RQT) complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation.

References:

[1]. Yoshitaka Matsuo, et al. Ubiquitination of stalled ribosome triggers ribosome-associated quality control. Nat Commun. 2017 Jul 31;8(1):159. [Content Brief]

[2]. Dong-Ju Jung, et al. Novel transcription coactivator complex containing activating signal cointegrator 1. Mol Cell Biol. 2002 Jul;22(14):5203-11. [Content Brief]

[3]. Satoshi Hashimoto, et al. Identification of a novel trigger complex that facilitates ribosome-associated quality control in mammalian cells. Sci Rep. 2020 Feb 25;10(1):3422. [Content Brief]

[4]. Sebastian Dango, et al. DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation. Mol Cell. 2011 Nov 4;44(3):373-84. [Content Brief]

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