Adhesion G protein-coupled receptor B2
Definition:
Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ. Involved in angiogenesis inhibition (By similarity).
References:
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[1]. Ryan H Purcell, et al. A disease-associated mutation in the adhesion GPCR BAI2 (ADGRB2) increases receptor signaling activity. Hum Mutat. 2017 Dec;38(12):1751-1760. [Content Brief]
[2]. Daisuke Okajima, et al. Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by proteolytic processing. J Recept Signal Transduct Res. 2010 Jun;30(3):143-53. [Content Brief]
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