Adhesion G protein-coupled receptor E2

Definition:

Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation.

References:

[1]. Simon Yona, et al. Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function. FASEB J. 2008 Mar;22(3):741-51. [Content Brief]

[2]. Jamila Gupte, et al. Signaling property study of adhesion G-protein-coupled receptors. FEBS Lett. 2012 Apr 24;586(8):1214-9. [Content Brief]

[3]. Steven E Boyden, et al. Vibratory Urticaria Associated with a Missense Variant in ADGRE2. N Engl J Med. 2016 Feb 18;374(7):656-63. [Content Brief]

[4]. Martin Stacey, et al. The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans. Blood. 2003 Oct 15;102(8):2916-24. [Content Brief]

[5]. Yi-Shu Huang, et al. Activation of myeloid cell-specific adhesion class G protein-coupled receptor EMR2 via ligation-induced translocation and interaction of receptor subunits in lipid raft microdomains. Mol Cell Biol. 2012 Apr;32(8):1408-20. [Content Brief]

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