AL amyloidosis
Definition:
Immunoglobulin light chain (AL) amyloidosis is the most common form of systemic amyloidosis. AL amyloidosis is a disorder of plasma cells or less commonly B cells that produce misfolded immunoglobulin light chain that deposits in tissues of a variety of organs causing organ dysfunction. Commonly affected organs include the heart, kidney, liver, soft tissues, peripheral and/or autonomic nerves, and the gastrointestinal tract.
References:
-
[1]. Giampaolo Merlini, et al. AL amyloidosis: from molecular mechanisms to targeted therapies. Hematology Am Soc Hematol Educ Program. 2017 Dec 8;2017(1):1-12. [Content Brief]
[2]. M Hasib Sidiqi, et al. Daratumumab for the treatment of AL amyloidosis. Leuk Lymphoma. 2019 Feb;60(2):295-301. [Content Brief]
Biomedical Dictionary
The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.
Molarity Calculator
Dilution Calculator
