Alpha-protein kinase 2

Definition:

Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling.

References:

[1]. Peter Hofsteen, et al. ALPK2 Promotes Cardiogenesis in Zebrafish and Human Pluripotent Stem Cells. iScience. 2018 Apr 27;2:88-100. [Content Brief]

[2]. A G Ryazanov, et al. Alpha-kinases: a new class of protein kinases with a novel catalytic domain. Curr Biol. 1999 Jan 28;9(2):R43-5. [Content Brief]

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